Expression of DBC1 and SIRT1 is associated with poor prognosis for breast carcinoma

• Published in: Human pathology 2011-02, Vol.42 (2), p.204-213
• Main Authors: Lee, Ho, MD, PhD, Kim, Kyung Ryoul, PhD, Noh, Sang Jae, MD, Park, Ho Sung, MD, PhD, Kwon, Keun Sang, MD, PhD, Park, Byung-Hyun, MD, PhD, Jung, Sung Hoo, MD, PhD, Youn, Hyun Jo, MD, PhD, Lee, Byoung Kil, MD, Chung, Myoung Ja, MD, PhD, Koh, Dai Ha, MD, PhD, Moon, Woo Sung, MD, PhD, Jang, Kyu Yun, MD, PhD
• Format: Article
• Language: English
• Subjects: Adaptor Proteins, Signal Transducing - metabolism; Antineoplastic Agents - therapeutic use; Apoptosis; Biological and medical sciences; Biomarkers, Tumor - metabolism; Breast; Breast cancer; Breast Neoplasms - metabolism; Breast Neoplasms - mortality; Breast Neoplasms - pathology; Cancer therapies; Carcinoma; Carcinoma, Ductal, Breast - metabolism; Carcinoma, Ductal, Breast - mortality; Carcinoma, Ductal, Breast - secondary; Cell cycle; Chemotherapy; Cloning; Deoxyribonucleic acid; DNA; Endocrine therapy; Female; Gynecology. Andrology. Obstetrics; Humans; Investigative techniques, diagnostic techniques (general aspects); Mammary gland diseases; Medical sciences; Middle Aged; Neoplasm Staging; Pathology; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Prognosis; Regression analysis; Republic of Korea - epidemiology; Review boards; Sirtuin 1 - metabolism; Sirtuins; Survival Rate; Therapy; Tumor Suppressor Protein p53 - metabolism; Tumors
• ISSN: 0046-8177; 1532-8392
• DOI: 10.1016/j.humpath.2010.05.023

Summary Recently, it has been reported that SIRT1 and DBC1 may be involved in the development of tumors and predict poor survival in some cancers. However, their exact role is not clear. Therefore, we investigated the expression status and clinical significance of DBC1 and SIRT1 expression in breast carcinomas. We evaluated the immunohistochemical expression of DBC1, SIRT1, and p53 using a 3-mm core from 122 patients with breast cancer for tissue microarray. Positive expression of DBC1 and SIRT1 were seen in 71% and 67% of patients, respectively. In the patients with breast cancer, overall, expression of DBC1 and SIRT1 was significantly associated with distant metastatic relapse and shorter relapse-free survival and overall survival by univariate analysis. Tumor stage and DBC1 and SIRT1 expression were also independent prognostic factors by multivariate analysis. Among the patients who had received chemotherapy, DBC1 and SIRT1 expression was significantly associated with distant metastatic relapse and shorter survival by univariate analysis. DBC1 expression was also associated with distant metastatic relapse and shorter survival in patients who had received endocrine therapy, according to univariate and multivariate analysis. In conclusion, this study shows that expression of DBC1 and SIRT1 is a significant prognostic indicator for breast carcinoma patients.