Asthma in pregnancy – Immunological changes and clinical management

Summary Asthma is one of the most common diseases complicating pregnancy and a risk factor for several maternal and fetal complications, posing a special challenge for physicians treating asthmatic pregnant women. Asthma influences the outcome of pregnancy and – vice versa – pregnancy affects asthma...

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Bibliographic Details
Published in:Respiratory medicine 2011-02, Vol.105 (2), p.159-164
Main Authors: Tamási, Lilla, Horváth, Ildikó, Bohács, Anikó, Müller, Veronika, Losonczy, György, Schatz, Michael
Format: Article
Language:English
Subjects:
Administration, Inhalation
Anti-Asthmatic Agents - administration & dosage
Asthma
Asthma - diagnosis
Asthma - drug therapy
Asthma - immunology
Biological and medical sciences
Birth weight
Chronic obstructive pulmonary disease, asthma
Clinical implications
Female
Fetal Development - immunology
Fetuses
Humans
Hypersensitivity
Immunity, Cellular
Immunological tolerance
Immunology
Immunoregulation
Lymphocytes
Lymphocytes T
Management
Medical sciences
Pneumology
Pregnancy
Pregnancy Complications - diagnosis
Pregnancy Complications - drug therapy
Pregnancy Complications - immunology
Pulmonary/Respiratory
Reviews
Risk factors
Womens health
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Summary:Summary Asthma is one of the most common diseases complicating pregnancy and a risk factor for several maternal and fetal complications, posing a special challenge for physicians treating asthmatic pregnant women. Asthma influences the outcome of pregnancy and – vice versa – pregnancy affects asthma severity with bidirectional immunological interactions that are currently being examined. Supporting pregnancy-induced immunotolerance is the observation that attenuation of allergic responses can be detected in controlled asthmatic pregnant patients. However, uncontrolled asthmatic pregnant women show significant asthma-associated immune reactions, such as diminished pregnancy specific regulatory T cell proliferation, that may – besides other factors – influence fetal growth. Uncontrolled, symptomatic asthma may increase the risk of adverse perinatal outcomes; thus adequate regular anti-asthmatic treatment resulting in optimal asthma control represents a vital need during pregnancy. This review summarizes immunological changes characterizing pregnancy in asthmatic women together with the clinical implications of asthma management during pregnancy.
ISSN:0954-6111
1532-3064
DOI:10.1016/j.rmed.2010.11.006