Murine Virus Leukaemogenesis: Relationship between Susceptibility and Immunodepression

PREVIOUS studies have demonstrated that infection of BALB/c mice with a murine leukaemia virus such as Friend disease virus (FDV) before challenge immunization results in a profound depression of both the primary and secondary immune response 1–8 . The degree of immunological deficiency was directly...

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Bibliographic Details
Published in:Nature (London) 1969-12, Vol.224 (5226), p.1318-1319
Main Authors: CEGLOWSKI, WALTER S., FRIEDMAN, HERMAN
Format: Article
Language:English
Subjects:
Animals
Friend murine leukemia virus - immunology
Humanities and Social Sciences
Immunosuppressive Agents
Inbreeding
letter
Leukemia, Experimental - immunology
Mice
multidisciplinary
Science
Science (multidisciplinary)
Spleen - immunology
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Summary:PREVIOUS studies have demonstrated that infection of BALB/c mice with a murine leukaemia virus such as Friend disease virus (FDV) before challenge immunization results in a profound depression of both the primary and secondary immune response 1–8 . The degree of immunological deficiency was directly related to the time interval between infection and immunization.
ISSN:0028-0836
1476-4687
DOI:10.1038/2241318a0