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The Conversion of Acetoacetate to Pyruvaldehyde
The oxidative decarboxylation of acetoacetate to pyruvaldehyde is catalyzed by sheep heart extracts in the presence of O 2 and Mn 2+ . The product was identified by spectral and chromatographic methods. From fractionation and inhibitor characteristics and the similarity of the catalytic activity to...
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Published in: | The Journal of biological chemistry 1967-03, Vol.242 (6), p.1095-1101 |
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Main Authors: | , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | The oxidative decarboxylation of acetoacetate to pyruvaldehyde is catalyzed by sheep heart extracts in the presence of O 2 and Mn 2+ . The product was identified by spectral and chromatographic methods. From fractionation and inhibitor characteristics and
the similarity of the catalytic activity to that of commercial myoglobin, it is concluded that the catalyst for the conversion
in sheep heart extracts is myoglobin. A free radical mechanism which would account for the characteristics and requirements
of the reaction is presented. |
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ISSN: | 0021-9258 1083-351X |
DOI: | 10.1016/S0021-9258(18)96149-1 |