Irreversible enzyme inhibitors. CLXVI. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 2,4-diamino-5-(3,4-dichlorophenyl)pyrimidine with 6 substituents and some factors in their cell wall transport

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Bibliographic Details
Published in:Journal of medicinal chemistry 1970-01, Vol.13 (1), p.82-86
Main Authors: Baker, Bernard Randall, Vermeulen, Nicolaas M. J
Format: Article
Language:English
Subjects:
Animals
Binding Sites
Biological Transport
Cell Wall - metabolism
Chemical Phenomena
Chemistry
Folic Acid Antagonists
Liver - enzymology
Mice
Pyrimidines - metabolism
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ISSN:0022-2623
1520-4804
DOI:10.1021/jm00295a021