Brain Norepinephrine: Enhanced Turnover after Rubidium Treatment

After biosynthesis of norepinephrine was inhibited, treatment of rats for 10 days with rubidium chloride (0.6 milliequivalent per kilogram of body weight) caused an increase in the rate of disappearance of norepinephrine in the brainstem but not in the telencephalon. Also the utilization of intracis...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1970-04, Vol.168 (3930), p.501-503
Main Authors: Stolk, Jon M., Nowack, William J., Barchas, Jack D., Platman, Stanley R.
Format: Article
Language:English
Subjects:
Animals
Brain Chemistry - drug effects
Brain stem
Brain Stem - metabolism
Catecholamines
Cats
Food chain
Lithium
Marine fishes
Metabolism
Norepinephrine
Norepinephrine - metabolism
Rats
Rubidium
Rubidium - pharmacology
Spectrophotometry
Telencephalon - metabolism
Tritium
Trophic levels
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Summary:After biosynthesis of norepinephrine was inhibited, treatment of rats for 10 days with rubidium chloride (0.6 milliequivalent per kilogram of body weight) caused an increase in the rate of disappearance of norepinephrine in the brainstem but not in the telencephalon. Also the utilization of intracisternally injected tritiated norepinephrine was increased and was accompanied by a shift in the pattern of norepinephrine metabolism to normetanephrine. These data suggest that greater amounts of neuronally stored norepinephrine were released to central adrenergic receptors.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.168.3930.501