Chromosomal Aberrations in Polycythemia Vera

A number of chromosomal aberrations, occurring in polycythemia vera patients are presented, with an emphasis on their nonspecific nature. Among radiophosphorus-treated patients the frequency of these aberrations was moderately higher. The one finding typical to P32 treated patients was the presence...

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Bibliographic Details
Published in:Blood 1970-01, Vol.35 (1), p.28-38
Main Authors: Modan, B., Padeh, B., Kallner, H., Akstein, E., Meytes, D., Czerniak, P., Ramot, B., Pinkhas, J., Modan, M.
Format: Article
Language:English
Subjects:
Aneuploidy
Bloodletting
Bone Marrow Cells
Chromosome Aberrations
Chromosomes, Human, 1-3
Colchicine - pharmacology
Culture Techniques
Humans
Karyotyping
Lectins - pharmacology
Leukocytes
Mitosis
Phlebography
Phosphorus Isotopes - therapeutic use
Polycythemia Vera - blood
Polycythemia Vera - genetics
Polycythemia Vera - therapy
Prospective Studies
Trisomy
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Summary:A number of chromosomal aberrations, occurring in polycythemia vera patients are presented, with an emphasis on their nonspecific nature. Among radiophosphorus-treated patients the frequency of these aberrations was moderately higher. The one finding typical to P32 treated patients was the presence of dicentric chromosomes, and a dose response curve to the last P32 dose was demonstrated. A Philadelphia-like chromosome was observed in two patients with polycythemia vera and in one with benign erythrocytosis, all post P32 therapy. A question is raised whether it is possible that the future course of the polycythemic patient is dependent upon the type and location of chromosomal damage, and in turn, on the establishment of a clone of cells with a selective developmental advantage.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V35.1.28.28