Bone Marrow and Spleen: Dissociation of Immunologic Properties by Cortisone

Bone marrow and spleen cells react differently after treatment with cortisone acetate in vivo. Antibody-forming, hematopoietic, and proliferative responses of spleen cells are reduced, while bone marrow cell responses are not. The stimulation of spleen cells by phytohemagglutinin is abolished, but t...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1970-03, Vol.167 (3924), p.1515-1517
Main Authors: Levine, Mark A., Claman, Henry N.
Format: Article
Language:English
Subjects:
Acetates
Animals
Antibodies
Antibody Formation - drug effects
Bone marrow
Bone Marrow - drug effects
Bone Marrow - immunology
Bone Marrow Cells
Cortisone - pharmacology
Cultured cells
Hematopoiesis - drug effects
Immunology
Iron - metabolism
Iron Isotopes
Lectins - pharmacology
Lymphocytes
Mice
Phytohemagglutinins
Scalp
Spleen
Spleen - drug effects
Spleen - immunology
Spleen cells
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Summary:Bone marrow and spleen cells react differently after treatment with cortisone acetate in vivo. Antibody-forming, hematopoietic, and proliferative responses of spleen cells are reduced, while bone marrow cell responses are not. The stimulation of spleen cells by phytohemagglutinin is abolished, but the response of marrow cells is enhanced. These reactions provide functional markers for the different cells involved in immunologic responses.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.167.3924.1515