Urinary Excretion Patterns of Individual Acid Mucopolysaccharides

DURING recent years several authors have shown that certain hereditary dysostoses are caused by an abnormal deposition in bone and various parenchymatous organs of acid mucopolysaccharides (AMP). Maroteaux and Lamy 1 subdivided these mucopolysaccharidoses into five different types according to their...

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Bibliographic Details
Published in:Nature (London) 1967-03, Vol.213 (5081), p.1132-1133
Main Author: TELLER, W. M
Format: Article
Language:English
Subjects:
Adult
Child
Child, Preschool
Chondroitin - urine
Chromatography, Ion Exchange
Female
Glycosaminoglycans - urine
Humanities and Social Sciences
Humans
Intellectual Disability - diagnosis
Intellectual Disability - urine
letter
Male
Mucopolysaccharidoses - diagnosis
Mucopolysaccharidoses - urine
multidisciplinary
Science
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Summary:DURING recent years several authors have shown that certain hereditary dysostoses are caused by an abnormal deposition in bone and various parenchymatous organs of acid mucopolysaccharides (AMP). Maroteaux and Lamy 1 subdivided these mucopolysaccharidoses into five different types according to their characteristic excretion patterns of AMP. In this communication we present our results of a comparable investigation of urinary excretion of individual AMP in normal persons and patients with different types of mucopolysaccharidoses. Through the introduction of column chromatography the determination of AMP pattern in the urine has become an especially valuable tool in the biochemical identification and classification of atypical cases of hereditary dysplasias of bone.
ISSN:0028-0836
1476-4687
DOI:10.1038/2131132a0