Mechanisms of pulsus alternans

The mechanisms of pulsus alternans were studied in three patients by cineangiographic determinations of left ventricular volume. In two patients with left ventricular disease, pulsus alternans occurred without detectable variation in left ventricular enddiastolic pressure (LVEDP) or end-diastolic vo...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1967-09, Vol.36 (3), p.372-380
Main Authors: Cohn, K E, Sandler, H, Hancock, E W
Format: Article
Language:English
Subjects:
Adult
Angiography
Aortic Valve Stenosis - physiopathology
Blood Pressure Determination
Blood Volume Determination
Cardiac Catheterization
Cardiac Complexes, Premature - physiopathology
Female
Heart Ventricles - physiopathology
Humans
Male
Middle Aged
Pulse - physiology
Space life sciences
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Summary:The mechanisms of pulsus alternans were studied in three patients by cineangiographic determinations of left ventricular volume. In two patients with left ventricular disease, pulsus alternans occurred without detectable variation in left ventricular enddiastolic pressure (LVEDP) or end-diastolic volume (EDV), although in the second case these values did alternate in the initial postextrasystolic beats. Another patient with normal left ventricular function had brief postextrasystolic pulsus alternans associated with LVEDV alternations. Twenty-nine patients with valvular aortic stenosis who showed pulsus alternans during left heart catheterization were also studied. Persistent alternation in LVEDP occurred in eight, with transient LVEDP alternation appearing after extrasystoles in 22 cases. Cardiac cycle length and diastolic interval alternation occurred inconsistently.
ISSN:0009-7322
1524-4539
DOI:10.1161/01.cir.36.3.372