Hemoglobin Polymorphism in White-Tailed Deer: Subunit Basis

A variety of aberrant erythrocyte forms have been related to seven adult and two fetal hemoglobins in white-tailed deer. While sickling of the erythrocyte was not associated with a single hemoglobin type, it was precluded by hemoglobin V or VII, even when in combination with other hemoglobin types n...

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Bibliographic Details
Published in:Blood 1967-06, Vol.29 (6), p.867-877
Main Authors: Kitchen, Hyram, Putnam, Frank W., Taylor, W. Jape
Format: Article
Language:English
Subjects:
Anemia, Sickle Cell
Animals
Artiodactyla
Blood Protein Electrophoresis
Erythrocytes
Hemoglobins - analysis
Hydrogen-Ion Concentration
In Vitro Techniques
Peptides - analysis
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Summary:A variety of aberrant erythrocyte forms have been related to seven adult and two fetal hemoglobins in white-tailed deer. While sickling of the erythrocyte was not associated with a single hemoglobin type, it was precluded by hemoglobin V or VII, even when in combination with other hemoglobin types normally associated with sickling. The subunit basis of the hemoglobin polymorphism was presented. Two kinds of α subunits, six kinds of β subunits and one γ subunit were related to the whole hemoglobin molecule. The heterogeneity of the deer hemoglobins was based upon a variety of combinations of these numerous polypeptide chains. It was concluded from the results of limited structural studies that there were multiple peptide differences upon comparison of three non-α polypeptide chains.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V29.6.867.867