Inhibition of Mouse Sarcoma 180 by a Wheat Hemicellulose B Preparation

WE have found that the polysaccharide preparation, termed hemicellulose B, isolated from wheat straw is highly active in inhibiting the growth and inducing regression of sarcoma 180 subcutaneously implanted in mice. The polysaccharide preparation has, however, only a slight effect on subcutaneous gr...

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Bibliographic Details
Published in:Nature (London) 1967-10, Vol.216 (5113), p.374-375
Main Authors: NAKAHARA, WARO, TOKUZEN, REIKO, FUKUOKA, FUMIKO, WHISTLER, ROY L
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - therapeutic use
Carcinoma, Ehrlich Tumor - drug therapy
Humanities and Social Sciences
Injections, Intraperitoneal
letter
Mice
multidisciplinary
Polysaccharides - therapeutic use
Sarcoma 180 - drug therapy
Science
Triticum - analysis
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Summary:WE have found that the polysaccharide preparation, termed hemicellulose B, isolated from wheat straw is highly active in inhibiting the growth and inducing regression of sarcoma 180 subcutaneously implanted in mice. The polysaccharide preparation has, however, only a slight effect on subcutaneous grafts of Ehrlich carcinoma and no recognizable effect on the growth of autologous grafts of spontaneous mammary adenocarcinomas. Certain polysaccharides from higher plants have been shown to inhibit growth of transplanted tumours, but the polymers also appeared toxic and none were well characterized 1–13 . Statolon from P. stoloniferium induces the production of interferon in animal cells 14 .
ISSN:0028-0836
1476-4687
DOI:10.1038/216374a0