Induced resistance of mice to a lymphoid strain of leukemia virus (moloney)

Live Moloney virus derived from chronically infected cell lines or infected mouse plasma stimulates formation of neutralizing antibodies in a susceptible mouse strain (BALB/c) and resistant mouse strains (C‐57/BL and BDF1). Inactivated tissue‐culture Moloney virus produces detectable neutralizing an...

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Bibliographic Details
Published in:Cancer 1967-07, Vol.20 (7), p.1124-1130
Main Authors: Mayyasi, S. A., Moloney, J. B.
Format: Article
Language:English
Subjects:
Animals
Antibody Formation
Culture Techniques
Immunization
Leukemia, Experimental - immunology
Mice
Moloney murine leukemia virus
Neutralization Tests
Vaccination
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Summary:Live Moloney virus derived from chronically infected cell lines or infected mouse plasma stimulates formation of neutralizing antibodies in a susceptible mouse strain (BALB/c) and resistant mouse strains (C‐57/BL and BDF1). Inactivated tissue‐culture Moloney virus produces detectable neutralizing antibodies in the resistant mouse but not the susceptible mouse strain. BALB/c mice immunized with live tissue‐culture attenuated Rauscher virus develop active immunity against challenge with tumor cells induced by Moloney virus.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(196707)20:7<1124::AID-CNCR2820200715>3.0.CO;2-3