Ion exchange chromatography of the free amino acids in the plasma of infants under 2,500 gm at birth

The free amino acids in the plasma of 46 infants who were under 2,500 gm at birth were determined by an ion exchange chromatographic technique of high sensitivity and resolution. Ninety-two plasma samples were collected from the 46 infants on different days after birth, and the data for 23 amino aci...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1970-04, Vol.45 (4), p.606-613
Main Authors: Dickinson, J C, Rosenblum, H, Hamilton, P B
Format: Article
Language:English
Subjects:
Amino Acids - blood
Birth Weight
Chromatography, Ion Exchange
Female
Humans
Infant, Newborn
Infant, Premature
Male
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Summary:The free amino acids in the plasma of 46 infants who were under 2,500 gm at birth were determined by an ion exchange chromatographic technique of high sensitivity and resolution. Ninety-two plasma samples were collected from the 46 infants on different days after birth, and the data for 23 amino acids plus taurine and ethanolamine were summarized and compared with newborn, full-term and adult levels. In 16 cases tyrosine levels were high; these values are listed separately. With respect to the remaining amino acids, many showed marked changes during the first few postnatal days; but, by the end of the first week, stable patterns had developed. The decrease or increase of the individual amino acid concentrations in these infants compared to infants with birth weights over 2,500 gm and to the adult was not great and seemed to be characteristic for each amino acid. Attention was drawn to the technical details of preparing and analyzing physiological fluids which would minimize the changes in amino acid concentrations resulting from improper handling.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.45.4.606