Central control of glucose homeostasis: the brain – endocrine pancreas axis

Abstract A large body of data gathered over the last decades has delineated the neuronal pathways that link the central nervous system with the autonomic innervation of the endocrine pancreas, which controls alpha- and beta-cell secretion activity and mass. These are important regulatory functions t...

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Bibliographic Details
Published in:Diabetes & metabolism 2010-10, Vol.36, p.S45-S49
Main Author: Thorens, B
Format: Article
Language:English
Subjects:
Animals
Autonomic Nervous System - physiology
Beta-cells
Biological and medical sciences
Brain Stem - metabolism
Brainstem
Cellules bêta
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinology & Metabolism
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Glucagon
Glucagon - metabolism
Glucose - metabolism
Homeostasis
Hypothalamus
Insulin
Insulin - metabolism
Insulin-Secreting Cells - metabolism
Insuline
Internal Medicine
Medical sciences
Mice
Review
Revue générale
Tronc cérébral
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Summary:Abstract A large body of data gathered over the last decades has delineated the neuronal pathways that link the central nervous system with the autonomic innervation of the endocrine pancreas, which controls alpha- and beta-cell secretion activity and mass. These are important regulatory functions that are certainly keys for preserving the capacity of the endocrine pancreas to control glucose homeostasis over a lifetime. Identifying the cells involved in controlling the autonomic innervation of the endocrine pancreas, in response to nutrient, hormonal and environmental cues and how these cues are detected to activate neuronal activity are important goals of current research. Elucidation of these questions may possibly lead to new means for preserving or restoring defects in insulin and glucagon secretion associated with type 2 diabetes.
ISSN:1262-3636
1878-1780
DOI:10.1016/S1262-3636(10)70466-3