Peroxidation of Subcellular Organelles: Formation of Lipofuscinlike Fluorescent Pigments

Lipid peroxidation of subcellular organelles gives fluorescent products which have fluorescence and excitation spectra similar to those of lipofuscin pigments. Fluorescence and excitation spectra and total fluorescence in the 460-nanometer region are useful for qualitative identification and quantit...

Full description

Saved in:
Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1969-12, Vol.166 (3912), p.1535-1536
Main Authors: Chio, K. S., Reiss, U., Fletcher, B., Tappel, A. L.
Format: Article
Language:English
Subjects:
Animals
Antioxidants - pharmacology
Cell cycle
Cell lines
Diploidy
DNA
DNA replication
Fluorescence
Lipid Peroxidation
Lipids
Lipofuscin - metabolism
Liver - metabolism
Liver - ultrastructure
Lysosomes - drug effects
Lysosomes - metabolism
Microsomes, Liver - drug effects
Microsomes, Liver - metabolism
Mitochondria, Liver - drug effects
Mitochondria, Liver - metabolism
Organelles
Pigments
Propyl Gallate - pharmacology
Rats
Schiff Bases - analysis
Somatic cells
Spectrometry, Fluorescence
Thiobarbituric Acid Reactive Substances - analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Lipid peroxidation of subcellular organelles gives fluorescent products which have fluorescence and excitation spectra similar to those of lipofuscin pigments. Fluorescence and excitation spectra and total fluorescence in the 460-nanometer region are useful for qualitative identification and quantitative measurement of the Schiff base product, a molecular damage site of lipid peroxidation which develops during some aging processes.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.166.3912.1535