Molecular Sieving by Glomerular Basement Membrane

OF the three layers of the glomerular capillary wall—endothelial cells, basement membrane and epithelial cells—the basement membrane appears to be the only complete barrier between the plasma and the glomerular filtrate 1,2 . Support for the view that the basement membrane is the most important filt...

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Bibliographic Details
Published in:Nature (London) 1967-10, Vol.216 (5110), p.87-88
Main Authors: HUANG, FLORA, HUTTON, LINDA, KALANT, NORMAN
Format: Article
Language:English
Subjects:
Animals
Basement Membrane - analysis
Basement Membrane - physiopathology
Carbon Isotopes
Chromatography, Gel
Humanities and Social Sciences
Kidney Glomerulus - analysis
Kidney Glomerulus - physiopathology
letter
Mannose
multidisciplinary
Nephrotic Syndrome - physiopathology
Permeability
Rats
Science
Science (multidisciplinary)
Serum Albumin, Radio-Iodinated
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Description
Summary:OF the three layers of the glomerular capillary wall—endothelial cells, basement membrane and epithelial cells—the basement membrane appears to be the only complete barrier between the plasma and the glomerular filtrate 1,2 . Support for the view that the basement membrane is the most important filtering mechanism was provided by the studies on ferritin transfer across the glomerular capillary wall 2–5 . Graham and Karnovsky 6 have concluded that the epithelial slits are the primary filtration barrier and suggested that glomerular basement membrane acts only as a “coarse” filter. It is thus still not established whether the basement membrane acts as a filter.
ISSN:0028-0836
1476-4687
DOI:10.1038/216087a0