Regeneration of Rat Liver: Transfer of Humoral Agent by Cross Circulation

Carotid-to-jugular cross circulation between partially hepatectomized and normal rats, via polyethylene cannulas, stimulated incorporation of $^{14}$C-thymidine into hepatic DNA in the normal partners when it was maintained for 19 hours at a flow rate of about 2 milliliters per minute. Cross circula...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1967-10, Vol.158 (3798), p.272-274
Main Authors: Moolten, Frederick L., Nancy L. R. Bucher
Format: Article
Language:English
Subjects:
Animals
Blood
Carbon Isotopes
Catheterization
Cross circulation
DNA - biosynthesis
Female
Hepatectomy
Hepatocytes
Liver
Liver - metabolism
Liver Regeneration
Mitosis
Parabiosis
Rats
Thymidine - metabolism
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Summary:Carotid-to-jugular cross circulation between partially hepatectomized and normal rats, via polyethylene cannulas, stimulated incorporation of $^{14}$C-thymidine into hepatic DNA in the normal partners when it was maintained for 19 hours at a flow rate of about 2 milliliters per minute. Cross circulation for 7 hours or less was ineffective.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.158.3798.272