Effects of Thymic Extract on the Neuromuscular Junction

THE abnormal development of skeletal muscle fatigue in myasbhenia gravis has been attributed to a circulating agent affecting neuromuscular transmission. A summary of the evidence relating to such agents is given by Bergh 1 . Substances with apparent neuromuscular blocking activity have been obtaine...

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Bibliographic Details
Published in:Nature (London) 1967-06, Vol.214 (5093), p.1116-1117
Main Authors: PARKES, J. D, MCKINNA, J. A
Format: Article
Language:English
Subjects:
Action Potentials
Antibodies
Autoimmune Diseases
Electromyography
Humanities and Social Sciences
Humans
letter
multidisciplinary
Muscle Contraction
Myasthenia Gravis - pathology
Neuromuscular Junction - drug effects
Science
Science (multidisciplinary)
Thymectomy
Thymus Gland
Thymus Hyperplasia
Tissue Extracts - pharmacology
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Summary:THE abnormal development of skeletal muscle fatigue in myasbhenia gravis has been attributed to a circulating agent affecting neuromuscular transmission. A summary of the evidence relating to such agents is given by Bergh 1 . Substances with apparent neuromuscular blocking activity have been obtained by extraction of the thymus glands from myasthenic patients, newborn infants, and a variety of animal species. The methods of thymic extraction have varied 2,3 , and results have not been invariably positive 4 . A definitive neuromuscular site of action of such agents has not been confirmed and the relationship between substances obtained from blood and those from the thymus gland is not clear.
ISSN:0028-0836
1476-4687
DOI:10.1038/2141116a0