Diclofenac fast-dissolving film: suppression of bitterness by a taste-sensing system

Context: The selection of a proper taste-masking agent (TMA) is a critical issue in the development of fast-dissolving films containing bitter drugs. Objective: This work is aimed to evaluate the suppression of the bitter taste of a maltodextrin fast-dissolving film loaded with 13.4 mg sodium diclof...

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Bibliographic Details
Published in:Drug development and industrial pharmacy 2011-03, Vol.37 (3), p.252-259
Main Authors: Cilurzo, Francesco, Cupone, Irma Elisa, Minghetti, Paola, Buratti, Susanna, Gennari, Chiara G.M., Montanari, Luisa
Format: Article
Language:English
Subjects:
Administration, Mucosal
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Anti-Inflammatory Agents, Non-Steroidal - chemistry
Bitter drug
Diclofenac - administration & dosage
Diclofenac - chemistry
Dosage Forms
Drug Compounding
Drug Delivery Systems
electronic tongue
Electronics
Flavoring Agents - chemistry
Humans
maltodextrin
Polysaccharides - chemistry
Solubility
Taste
taste-masking agent
Technology, Pharmaceutical - methods
tensile properties
Tensile Strength
Tongue
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Summary:Context: The selection of a proper taste-masking agent (TMA) is a critical issue in the development of fast-dissolving films containing bitter drugs. Objective: This work is aimed to evaluate the suppression of the bitter taste of a maltodextrin fast-dissolving film loaded with 13.4 mg sodium diclofenac (DS) by adding TMAs. Methods: The films were prepared by casting and drying aqueous mixtures of maltodextrin (DE = 6), glycerin, sorbitan oleate, and DS. Films were characterized in terms of thickness, tensile properties, film disintegration time, and drug dissolution time. The bitterness intensity of DS and the masking effect of TMAs were evaluated by an electronic tongue. Results: The 'mint' and 'licorice' flavors and sucralose mixture resulted appropriate to mask DS bitterness as confirmed by a panel of volunteers. The addition of these TMAs did not significantly affect the film disintegration time (15-20 seconds) and DS dissolution rate (about 5 minutes). Conclusion: The electronic tongue was allowed to discriminate the effect of the TMA also in the presence of other hydrosoluble constituents of the film. Therefore, because of its simplicity and rapidity, this technique could assist or even replace the sensory evaluation in the development of fast-dissolving films.
ISSN:0363-9045
1520-5762
DOI:10.3109/03639045.2010.505928