Radioactive synovectomy with Yttrium90 citrate in haemophilic synovitis: Brazilian experience

• Published in: Haemophilia : the official journal of the World Federation of Hemophilia 2011-01, Vol.17 (1), p.e211-e216
• Main Authors: THOMAS, S., GABRIEL, M. B., ASSI, P. E., BARBOZA, M., PERRI, M. L. P., LAND, M. G. P., DA COSTA, E. S.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Child; Child, Preschool; Citrates - therapeutic use; Factor VIII - antagonists & inhibitors; Female; haemophilia; Hemarthrosis - complications; Hemophilia A - complications; Hemophilia B - complications; Humans; Infant; inhibitors; Male; Middle Aged; Organometallic Compounds - therapeutic use; Pain Measurement; radioactive synovectomy; Radioisotopes - therapeutic use; Range of Motion, Articular; synovitis; Synovitis - etiology; Synovitis - radiotherapy; von Willebrand disease; von Willebrand Diseases - complications; Young Adult; Yttrium
• ISSN: 1351-8216; 1365-2516
• DOI: 10.1111/j.1365-2516.2010.02379.x

Recurrent haemarthroses leading to chronic synovitis and arthropathy remain a major cause of morbidity in patients with haemophilia. Radioactive synovectomy (RS) is considered the first choice of treatment for chronic haemophilic synovitis. The aim of this study was to evaluate the effect of RS with Yttrium90 citrate (C‐Y90) in the joints of patients with chronic haemophilic synovitis. From 2003 to 2007, 245 joints (118 knees, 76 elbows, 49 ankles and two shoulders) of 190 patients with haemophilia or von Willebrand disease were submitted to RS with C‐Y90 at Hemocentro de Mato Grosso, Brazil. Forty joints had radiographic Pettersson scores above 8. There were 36 joints of 22 patients with inhibitors to factor VIII. The procedure was safe with low occurrence of adverse events. The main effect was the overall reduction in joint bleeding frequency, from 19.8 to 2.6 per year post‐RS. Similar results were obtained in cases with high radiographic scores and in inhibitor patients. Pain reduction was observed in most cases. Average range of motion was maintained or increased 1 year post‐RS in most joints. Extension was stable or increased in 88.2% of the knees and 86.5% of the elbows. Ankle plantarflexion was stable or increased in 90.9%, whereas dorsiflexion was maintained or increased in 87.9%. Worsening of the range of motion, when present, ranged from 14 to 17 degrees. We concluded that RS with C‐Y90 represents an important resource for the treatment of chronic haemophilic synovitis, markedly reducing joint bleeding frequency and pain, irrespective of the radiographic stage and inhibitor status.