Application of Electron Probe Microanalysis and Electron Microscopy to the Transfer of Antigenic Material

WE have studied the effect of various antilymphocyte sera on lymphocytes, using the Stereoscan electron microscope 1 , and more recently we described the formation of long intercellular processes between macrophages and lymphocytes in certain conditions 2 . Process formation was particularly marked...

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Bibliographic Details
Published in:Nature (London) 1970-07, Vol.227 (5253), p.69-71
Main Authors: CLARKE, J. A, SALSBURY, A. J, WILLOUGHBY, D. A
Format: Article
Language:English
Subjects:
Animals
Antigens
Cell Membrane - immunology
Electron Probe Microanalysis
Humanities and Social Sciences
In Vitro Techniques
Intercellular Junctions - immunology
Iodine - analysis
letter
Lymph Nodes - cytology
Lymphocytes - immunology
Macrophages - immunology
Microscopy, Electron
multidisciplinary
Rats
Science
Science (multidisciplinary)
Tuberculin
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Summary:WE have studied the effect of various antilymphocyte sera on lymphocytes, using the Stereoscan electron microscope 1 , and more recently we described the formation of long intercellular processes between macrophages and lymphocytes in certain conditions 2 . Process formation was particularly marked if macrophages from rats sensitized to tuberculin were incubated first with PPD and then with either normal lymph node cells or lymph node cells from rats sensitized to tuberculin (Fig. 1). In the former case, many macrophages were seen to be closely surrounded by clusters of lymphocytes.
ISSN:0028-0836
1476-4687
DOI:10.1038/227069a0