Potassium Ions and the Binding of Cardiac Glycosides to Mammalian Cells

The actions of the cardiac glycosides are antagonized by K + . This results from a reduction in the rate of combination of glycoside with its receptors.

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Bibliographic Details
Published in:Nature (London) 1970-05, Vol.226 (5245), p.521-523
Main Authors: BAKER, P. F, WILLIS, J. S
Format: Article
Language:English
Subjects:
Binding Sites
Biological Transport, Active
Cardiac Glycosides - antagonists & inhibitors
HeLa Cells
Humanities and Social Sciences
multidisciplinary
Ouabain - antagonists & inhibitors
Potassium - pharmacology
Science
Science (multidisciplinary)
Sodium - pharmacology
Tritium
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Description
Summary:The actions of the cardiac glycosides are antagonized by K + . This results from a reduction in the rate of combination of glycoside with its receptors.
ISSN:0028-0836
1476-4687
DOI:10.1038/226521a0