Mode of Action of Chloroquine on Plasmodium berghei and P. cynomolgi

THIS communication describes an investigation of the effects of chloroquine treatment on the ultrastructure of Plasmodium berghei in the mouse and rat, and of P. cynomolgi in the rhesus monkey. Chloroquine was given to the animals intraperitoneally in doses which produced a detectable reduction in p...

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Bibliographic Details
Published in:Nature (London) 1967-05, Vol.214 (5091), p.935-936
Main Authors: WARHURST, D. C., HOCKLEY, D. J.
Format: Article
Language:English
Subjects:
Animals
Chloroquine - pharmacology
Cytoplasm
Erythrocytes - drug effects
Haplorhini
Hemoglobins - metabolism
Humanities and Social Sciences
letter
Lysosomes
Mice
Microscopy, Electron
multidisciplinary
Plasmodium - cytology
Plasmodium - drug effects
Rats
Science
Science (multidisciplinary)
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Summary:THIS communication describes an investigation of the effects of chloroquine treatment on the ultrastructure of Plasmodium berghei in the mouse and rat, and of P. cynomolgi in the rhesus monkey. Chloroquine was given to the animals intraperitoneally in doses which produced a detectable reduction in parasitaemia on the day after administration (50, 95 and 17.5 mg/kg respectively). Blood samples were fixed for electron microscopy (2.5 per cent to 5 per cent glutaraldehyde followed by 1 per cent osmic acid) before and after injection of the drug.
ISSN:0028-0836
1476-4687
DOI:10.1038/214935a0