Mechanism of decreased myocardial contractile force after epicardiectomy

Myocardial contractile force measured by strain gauge arches recording from multiple ventricular and atrial sites was determined after bilateral cervical vagotomy, bilateral stellate ganglion excision, infusion of β-adrenergic blocking agents, and epicardiectomy. After all procedures except vagotomy...

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Bibliographic Details
Published in:Cardiovascular research 1970-04, Vol.4 (2), p.154-159
Main Authors: Kaye, Michael P., Randall, Walter C.
Format: Article
Language:English
Subjects:
Adrenergic beta-Antagonists - pharmacology
Animals
Atrial Function
Dogs
Heart - innervation
Heart - physiology
Muscle Contraction
Parasympathetic Nervous System - physiology
Pericardium - surgery
Stellate Ganglion - physiology
Sympathectomy
Sympathetic Nervous System - physiology
Vagotomy
Ventricular Function
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Summary:Myocardial contractile force measured by strain gauge arches recording from multiple ventricular and atrial sites was determined after bilateral cervical vagotomy, bilateral stellate ganglion excision, infusion of β-adrenergic blocking agents, and epicardiectomy. After all procedures except vagotomy, reductions in myocardial contractile force occurred. These data suggest that epicardiectomy results in release of the heart from tonic sympathetic control comparable with that following stellatectomy and administration of β-blocking agents. The normal balance between sympathetic and parasympathetic tonic discharge is disrupted by this procedure.
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/4.2.154