Characteristics of a Human Diploid Cell Designated MRC-5

THE stability and integrity of the human foetal cell strain WI-38, which has been well demonstrated in the past ten years 1–3 , and its susceptibility to viruses infective for man 1,4 , explain the value of such material for the isolation of viruses and in the development of vaccines 5–8 . We have d...

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Bibliographic Details
Published in:Nature (London) 1970-07, Vol.227 (5254), p.168-170
Main Authors: JACOBS, J. P., JONES, C. M., BAILLE, J. P.
Format: Article
Language:English
Subjects:
Adenoviridae
Aneuploidy
Arboviruses
Cell Line
Chromosome Aberrations
Culture Techniques
Cytopathogenic Effect, Viral
Diploidy
Enterovirus
Enterovirus B, Human
HeLa Cells
Herpesviridae
Humanities and Social Sciences
Humans
letter
Lung
Measles virus
Microscopy, Phase-Contrast
multidisciplinary
Polyploidy
Rhinovirus
Rubella virus
Science
Science (multidisciplinary)
Vaccinia virus
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Summary:THE stability and integrity of the human foetal cell strain WI-38, which has been well demonstrated in the past ten years 1–3 , and its susceptibility to viruses infective for man 1,4 , explain the value of such material for the isolation of viruses and in the development of vaccines 5–8 . We have developed another strain of cells, also derived from foetal lung tissue, taken from a 14-week male foetus removed for psychiatric reasons from a 27 year old woman with a genetically normal family history and no sign of neoplastic disease both at abortion and for at least three years afterwards. The criteria used for characterizing the cells are those recommended internationally 2,9 .
ISSN:0028-0836
1476-4687
DOI:10.1038/227168a0