USP Collaborative Study of the Assay of Atropine and Scopolamine Dosage Forms

Several tablet and injection dosage forms of atropine and scopolamine are covered by USP XVIII monographs.Gas chromatographic unit dose assay and content uniformity procedures were developed for these monographs.Interlaboratory reliability was evaluated by means of a collaborative study.The methods...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1970-09, Vol.59 (9), p.1324-1328
Main Authors: Grady, Lee T., Zimmerer, Rupert O.
Format: Article
Language:English
Subjects:
analysis-collaborative study
Atropine
Atropine - analysis
atropine dosage forms
Atropine, scopolamine dosage forms—analysis
Chromatography, Gas
Content uniformity method-atropine
Content uniformity method—atropine, scopolamine dosage forms
Dosage Forms - standards
GLC-analysis
Injections - standards
Methods
Pharmacopoeias as Topic
Scopolamine
Scopolamine - analysis
scopolamine dosage forms
scopolamine dosage forms-analysis
Scopolamine, atropine dosage forms, analysis—collaborative study
Tablets - standards
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Description
Summary:Several tablet and injection dosage forms of atropine and scopolamine are covered by USP XVIII monographs.Gas chromatographic unit dose assay and content uniformity procedures were developed for these monographs.Interlaboratory reliability was evaluated by means of a collaborative study.The methods afford substantial improvements in sensitivity, specificity, and speed over previous official methods.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600590923