Autoradiographic Study of the Effects of Cortisol on DNA Synthesis in Lymphatic Tissue

THE inter-relationships between adrenal corticosteroids and lymphatic tissue have often been described. The involution of lymphatic tissue produced by adrenal corticosteroids can be related to different aspects of the growth of lymphatic tissue and to the metabolism of lymphocytes. The effects on gr...

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Bibliographic Details
Published in:Nature (London) 1967-12, Vol.216 (5118), p.934-936
Main Authors: LANG, ROBERT F, STEVENS, WALTER, DOUGHERTY, THOMAS F
Format: Article
Language:English
Subjects:
Animals
Autoradiography
Carbon Isotopes
DNA - biosynthesis
Humanities and Social Sciences
Hydrocortisone - pharmacology
letter
Lymph Nodes - metabolism
Lymphoid Tissue - metabolism
Male
Mice
multidisciplinary
Science
Science (multidisciplinary)
Spleen - metabolism
Thymidine - metabolism
Thymus Gland - metabolism
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Summary:THE inter-relationships between adrenal corticosteroids and lymphatic tissue have often been described. The involution of lymphatic tissue produced by adrenal corticosteroids can be related to different aspects of the growth of lymphatic tissue and to the metabolism of lymphocytes. The effects on growth of lymphatic tissue are a combination of lymphocytokaryorrhexis and the inhibition of mitosis 1 . Metabolic effects include inhibition of DNA synthesis 2,3 , RNA synthesis 3,4 , protein synthesis 3,5–7 and glucose utilization 7–9 , as well as producing changes in certain enzymes 10 .
ISSN:0028-0836
1476-4687
DOI:10.1038/216934a0