EVALUATION OF GROUP C MENINGOCOCCAL POLYSACCHARIDE VACCINE IN MARINE RECRUITS, SAN DIEGO, CALIFORNIA

Devine, L. F., W. E. Pierce, T. M. Floyd, S. L. Rhode, E. A. Edwards, E. E. Siess and R. O. Peckinpaugh (Naval Medical Research Unit No. 4, Great Lakes, Illinois 60088). Evaluation of group C meningococcal polysaccharide vaccine in Marine recruits, San Diego, California. Amer. J. Epid., 1970, 92; 25...

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Bibliographic Details
Published in:American journal of epidemiology 1970-07, Vol.92 (1), p.25-32
Main Authors: DEVINE, LEONARD F., PIERCE, WILLARD E., FLOYD, THOMAS M., RHODE, SOLON L., EDWARDS, EARL A., SIESS, EUGENE E., PECKINPAUGH, ROBERT O.
Format: Article
Language:English
Subjects:
Adult
Antibodies
California
carrier state
Complement Fixation Tests
Drug Resistance, Microbial
group C meningococcal polysaccharide
Hemagglutination Inhibition Tests
Humans
Male
meningococcal infections
Meningococcal Infections - prevention & control
Naval Medicine
Neisseria meningitidis
Neisseria meningitidis - immunology
Polysaccharides, Bacterial - analysis
recruits
Sulfadiazine - pharmacology
vaccine
Vaccines - standards
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Summary:Devine, L. F., W. E. Pierce, T. M. Floyd, S. L. Rhode, E. A. Edwards, E. E. Siess and R. O. Peckinpaugh (Naval Medical Research Unit No. 4, Great Lakes, Illinois 60088). Evaluation of group C meningococcal polysaccharide vaccine in Marine recruits, San Diego, California. Amer. J. Epid., 1970, 92; 25–32.—Group C meningococcal polysaccharide vaccine was administered to 3, 018 Marine recruits. The vaccine appeared to be group-specific since it prevented the acquisition of only group C meningococci. The vaccine stimulated a good hemagglutinating antibody response, but did not stimulate a complement fixing antibody response. One systemic illness of uncertain etiology, possibly vaccine related, was observed among the vaccinees. That the vaccine affords protection against clinical disease was suggested when three cases of meningococcal disease of group C etiology developed in the nonvaccinated controls while none occurred among the vaccinated men of the study population.
ISSN:0002-9262
1476-6256
DOI:10.1093/oxfordjournals.aje.a121176