Release of Dopamine-β-hydroxylase with Norepinephrine during Cat Splenic Nerve Stimulation

DOPAMINE-β-HYDROXYLASE is released from the catecholamine storage vesicles of the adrenal medulla together with epinephrine 1 . The ratio of released catecholamine to enzyme is similar to that found in the soluble contents of these vesicles. Douglas and Poisner 2 found that adenosine triphosphate (A...

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Bibliographic Details
Published in:Nature (London) 1970-07, Vol.227 (5256), p.406-407
Main Authors: GEWIRTZ, GEORGE P, KOPIN, IRWIN J
Format: Article
Language:English
Subjects:
Adrenal Medulla - metabolism
Animals
Cats
Cytoplasmic Granules
Dopamine
Ganglia, Autonomic - enzymology
Ganglia, Autonomic - metabolism
Humanities and Social Sciences
In Vitro Techniques
letter
Mixed Function Oxygenases - metabolism
multidisciplinary
Norepinephrine - metabolism
Octopamine - biosynthesis
Perfusion
Science
Science (multidisciplinary)
Spleen - enzymology
Spleen - innervation
Spleen - metabolism
Tritium
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Summary:DOPAMINE-β-HYDROXYLASE is released from the catecholamine storage vesicles of the adrenal medulla together with epinephrine 1 . The ratio of released catecholamine to enzyme is similar to that found in the soluble contents of these vesicles. Douglas and Poisner 2 found that adenosine triphosphate (ATP) was released during such adrenal stimulation and proposed that adrenal secretion takes place by a process of exocytosis (that is, emptying of the contents of the nerve vesicles).
ISSN:0028-0836
1476-4687
DOI:10.1038/227406a0