Effect of Surface Charge on the Steady-state Potassium Conductance of Nodal Membrane

THE curve relating membrane conductance ( G m ) to membrane potential ( V m ) shifts along the voltage axis with changes in concentration of external divalent ions 1–4 , external p H 5 and internal ionic strength 6 . These findings are in qualitative agreement with the suggestion made by Huxley 1 th...

Full description

Saved in:
Bibliographic Details
Published in:Nature (London) 1970-10, Vol.228 (5267), p.164-165
Main Authors: MOZHAYEVA, G. N, NAUMOV, A. P
Format: Article
Language:English
Subjects:
Binding Sites
Calcium - metabolism
Electric Conductivity
Humanities and Social Sciences
Hydrogen-Ion Concentration
letter
Membrane Potentials
Membranes - physiology
multidisciplinary
Myelin Sheath - physiology
Osmolar Concentration
Potassium - metabolism
Ranvier's Nodes - physiology
Science
Science (multidisciplinary)
Surface Properties
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:THE curve relating membrane conductance ( G m ) to membrane potential ( V m ) shifts along the voltage axis with changes in concentration of external divalent ions 1–4 , external p H 5 and internal ionic strength 6 . These findings are in qualitative agreement with the suggestion made by Huxley 1 that the shift may correspond to changes in the electric field resulting from changes in the membrane surface potential, ψ 0 . To test the validity of the suggestion experimental shifts need to be compared with calculated changes in ψ 0 when ψ 0 is affected by various factors. While calculating ψ 0 it is essential to use the same basic assumptions concerning the charge number and chemical nature of adsorbing groups (binding sites) on the membrane surface. To this end, we studied the effect of changes in the external concentrations of H + , Ca 2+ , Mg 2+ , Co 2+ , Ni 2+ and external ionic strength on steadystate potassium conductance ( G m – V m curves).
ISSN:0028-0836
1476-4687
DOI:10.1038/228164a0