EXPRESSION OF TOLL-LIKE RECEPTOR 4, CD14, AND NF-κB IN CHINESE PATIENTS WITH ULCERATIVE COLITIS

This study elucidates the significance of Toll-like receptor 4 (TLR4), CD14, and nuclear factor (NF)-κB on the pathogenesis of ulcerative colitis (UC). Colonic biopsy specimens were collected from active UC and controls. The expression of TLR4, CD14, and NF-κBp 65 was analyzed by immunohistochemistr...

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Published in:Journal of immunoassay & immunochemistry 2011-01, Vol.32 (1), p.47-56
Main Authors: Yu, Zhen-hai, Huang, Fei, Xu, Ning, Zhao, Dong-mei, Hu, Feng-ai, Liu, Jiao, Liu, Hong-fu
Format: Article
Language:English
Subjects:
Adult
Aged
Asian Continental Ancestry Group - genetics
CD14
Colitis, Ulcerative - metabolism
Colitis, Ulcerative - pathology
Colon - metabolism
Female
Humans
Intestinal Mucosa - metabolism
Lipopolysaccharide Receptors - biosynthesis
Male
Middle Aged
NF-κB
Toll-like receptor 4
Toll-Like Receptor 4 - biosynthesis
Transcription Factor RelA - biosynthesis
ulcerative colitis
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Summary:This study elucidates the significance of Toll-like receptor 4 (TLR4), CD14, and nuclear factor (NF)-κB on the pathogenesis of ulcerative colitis (UC). Colonic biopsy specimens were collected from active UC and controls. The expression of TLR4, CD14, and NF-κBp 65 was analyzed by immunohistochemistry (IHC) and reverse-transcription polymerase chain reaction (RT-PCR). In UC, disease activity index (DAI) and pathological grade were classified according to the Powell-Tuck grade system and Truelove-Richards system, respectively. Fifty-six UC cases and 56 controls entered the investigation. IHC and RT-PCR revealed a significant increase of TLR4, CD14, and NF-κBp 65 antigen expression in colonic mucosa of UC compared with colonic mucosa of controls (p 
ISSN:1532-1819
1532-4230
DOI:10.1080/15321819.2010.538108