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Daily Red Wine Consumption Improves Vascular Function by a Soluble Guanylyl Cyclase-Dependent Pathway
Background Polyphenols in red wine are supposed to improve endothelial function. We investigated whether daily red wine consumption improves in-vivo vascular function by reducing endothelin-1 (ET-1). Additional pathways mediating this effect were studied using porcine coronary arteries (PCAs). Metho...
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| Published in: | American journal of hypertension 2011-02, Vol.24 (2), p.162-168 |
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| creator | Botden, Ilse P.G. Langendonk, Janneke G. Meima, Marcel E. Boomsma, Frans Seynhaeve, Ann L.B. Hagen, Timo L.M. ten Danser, A.H. Jan Sijbrands, Eric J.G. |
| description | Background
Polyphenols in red wine are supposed to improve endothelial function. We investigated whether daily red wine consumption improves in-vivo vascular function by reducing endothelin-1 (ET-1). Additional pathways mediating this effect were studied using porcine coronary arteries (PCAs).
Methods
Eighteen young healthy women drank red wine daily for 3 weeks. Vascular function was evaluated by determining forearm blood flow (FBF) responses to endothelium-dependent (acetylcholine
(ACh)) and endothelium-independent (sodium nitroprusside (SNP)) vasodilators. PCAs were suspended in organ baths and exposed to the endothelium-dependent vasodilator bradykinin, the nitric oxide (NO) donor S-nitroso-N-acetyl-l,l-penicillamine (SNAP) and/or red wine extract (RWE).
Results
ACh-induced and SNP-induced FBF increases were equally enhanced after 3 weeks of red wine consumption, but an immediate enhancement (i.e., after drinking the first glass) was not observed. Vice versa, plasma ET-1 levels were not decreased after 3 weeks, but we observed an acute drop after drinking one glass of wine. RWE relaxed preconstricted PCAs in an endothelium-, NO-, and soluble guanylyl cyclase (sGC)/guanosine-3′,5′-cyclic monophosphate (cGMP)-dependent manner. Short RWE exposure reduced the response to bradykinin and SNAP by inactivating sGC. This effect disappeared upon prolonged RWE exposure.
Conclusions
The enhanced FBF response following 3 weeks of red wine consumption, but not after one glass, reflects a change in smooth muscle sensitivity. Alterations in sGC responsiveness/activity, rather than changes in ET-1, appear to underlie this phenomenon.
American Journal of Hypertension,advance online publication 18 November 2010; doi:10.1038/ajh.2010.227 |
| doi_str_mv | 10.1038/ajh.2010.227 |
| format | article |
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Polyphenols in red wine are supposed to improve endothelial function. We investigated whether daily red wine consumption improves in-vivo vascular function by reducing endothelin-1 (ET-1). Additional pathways mediating this effect were studied using porcine coronary arteries (PCAs).
Methods
Eighteen young healthy women drank red wine daily for 3 weeks. Vascular function was evaluated by determining forearm blood flow (FBF) responses to endothelium-dependent (acetylcholine
(ACh)) and endothelium-independent (sodium nitroprusside (SNP)) vasodilators. PCAs were suspended in organ baths and exposed to the endothelium-dependent vasodilator bradykinin, the nitric oxide (NO) donor S-nitroso-N-acetyl-l,l-penicillamine (SNAP) and/or red wine extract (RWE).
Results
ACh-induced and SNP-induced FBF increases were equally enhanced after 3 weeks of red wine consumption, but an immediate enhancement (i.e., after drinking the first glass) was not observed. Vice versa, plasma ET-1 levels were not decreased after 3 weeks, but we observed an acute drop after drinking one glass of wine. RWE relaxed preconstricted PCAs in an endothelium-, NO-, and soluble guanylyl cyclase (sGC)/guanosine-3′,5′-cyclic monophosphate (cGMP)-dependent manner. Short RWE exposure reduced the response to bradykinin and SNAP by inactivating sGC. This effect disappeared upon prolonged RWE exposure.
Conclusions
The enhanced FBF response following 3 weeks of red wine consumption, but not after one glass, reflects a change in smooth muscle sensitivity. Alterations in sGC responsiveness/activity, rather than changes in ET-1, appear to underlie this phenomenon.
American Journal of Hypertension,advance online publication 18 November 2010; doi:10.1038/ajh.2010.227</description><identifier>ISSN: 0895-7061</identifier><identifier>EISSN: 1879-1905</identifier><identifier>EISSN: 1941-7225</identifier><identifier>DOI: 10.1038/ajh.2010.227</identifier><identifier>PMID: 21088673</identifier><identifier>CODEN: AJHYE6</identifier><language>eng</language><publisher>Basingstoke: Oxford University Press</publisher><subject>Adult ; Alcohol Drinking ; Animals ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Biomarkers - blood ; Blood and lymphatic vessels ; Blood vessels and receptors ; Cardiology. Vascular system ; Cells, Cultured ; Coronary Vessels - drug effects ; Coronary Vessels - enzymology ; Dose-Response Relationship, Drug ; Endothelial Cells - drug effects ; Endothelial Cells - enzymology ; Endothelin-1 - blood ; Female ; Forearm - blood supply ; Fundamental and applied biological sciences. Psychology ; Guanylate Cyclase - metabolism ; Humans ; In Vitro Techniques ; Medical sciences ; Muscle, Smooth, Vascular - drug effects ; Muscle, Smooth, Vascular - enzymology ; Nitric Oxide - metabolism ; Perfusion ; Plethysmography ; Receptors, Cytoplasmic and Nuclear - metabolism ; Regional Blood Flow - drug effects ; Signal Transduction - drug effects ; Soluble Guanylyl Cyclase ; Swine ; Time Factors ; Vasodilation - drug effects ; Vasodilator Agents - pharmacology ; Vertebrates: cardiovascular system ; Wine ; Young Adult</subject><ispartof>American journal of hypertension, 2011-02, Vol.24 (2), p.162-168</ispartof><rights>American Journal of Hypertension, Ltd. © 2011 by the American Journal of Hypertension, Ltd. 2011</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Feb 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-a130cbcaaa8af043d969b9c366d738d34aefaba6d51e60f315094905e9f91f5c3</citedby><cites>FETCH-LOGICAL-c443t-a130cbcaaa8af043d969b9c366d738d34aefaba6d51e60f315094905e9f91f5c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23955783$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21088673$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Botden, Ilse P.G.</creatorcontrib><creatorcontrib>Langendonk, Janneke G.</creatorcontrib><creatorcontrib>Meima, Marcel E.</creatorcontrib><creatorcontrib>Boomsma, Frans</creatorcontrib><creatorcontrib>Seynhaeve, Ann L.B.</creatorcontrib><creatorcontrib>Hagen, Timo L.M. ten</creatorcontrib><creatorcontrib>Danser, A.H. Jan</creatorcontrib><creatorcontrib>Sijbrands, Eric J.G.</creatorcontrib><title>Daily Red Wine Consumption Improves Vascular Function by a Soluble Guanylyl Cyclase-Dependent Pathway</title><title>American journal of hypertension</title><addtitle>Am J Hypertens</addtitle><description>Background
Polyphenols in red wine are supposed to improve endothelial function. We investigated whether daily red wine consumption improves in-vivo vascular function by reducing endothelin-1 (ET-1). Additional pathways mediating this effect were studied using porcine coronary arteries (PCAs).
Methods
Eighteen young healthy women drank red wine daily for 3 weeks. Vascular function was evaluated by determining forearm blood flow (FBF) responses to endothelium-dependent (acetylcholine
(ACh)) and endothelium-independent (sodium nitroprusside (SNP)) vasodilators. PCAs were suspended in organ baths and exposed to the endothelium-dependent vasodilator bradykinin, the nitric oxide (NO) donor S-nitroso-N-acetyl-l,l-penicillamine (SNAP) and/or red wine extract (RWE).
Results
ACh-induced and SNP-induced FBF increases were equally enhanced after 3 weeks of red wine consumption, but an immediate enhancement (i.e., after drinking the first glass) was not observed. Vice versa, plasma ET-1 levels were not decreased after 3 weeks, but we observed an acute drop after drinking one glass of wine. RWE relaxed preconstricted PCAs in an endothelium-, NO-, and soluble guanylyl cyclase (sGC)/guanosine-3′,5′-cyclic monophosphate (cGMP)-dependent manner. Short RWE exposure reduced the response to bradykinin and SNAP by inactivating sGC. This effect disappeared upon prolonged RWE exposure.
Conclusions
The enhanced FBF response following 3 weeks of red wine consumption, but not after one glass, reflects a change in smooth muscle sensitivity. Alterations in sGC responsiveness/activity, rather than changes in ET-1, appear to underlie this phenomenon.
American Journal of Hypertension,advance online publication 18 November 2010; doi:10.1038/ajh.2010.227</description><subject>Adult</subject><subject>Alcohol Drinking</subject><subject>Animals</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Blood and lymphatic vessels</subject><subject>Blood vessels and receptors</subject><subject>Cardiology. Vascular system</subject><subject>Cells, Cultured</subject><subject>Coronary Vessels - drug effects</subject><subject>Coronary Vessels - enzymology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Endothelial Cells - drug effects</subject><subject>Endothelial Cells - enzymology</subject><subject>Endothelin-1 - blood</subject><subject>Female</subject><subject>Forearm - blood supply</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Guanylate Cyclase - metabolism</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Medical sciences</subject><subject>Muscle, Smooth, Vascular - drug effects</subject><subject>Muscle, Smooth, Vascular - enzymology</subject><subject>Nitric Oxide - metabolism</subject><subject>Perfusion</subject><subject>Plethysmography</subject><subject>Receptors, Cytoplasmic and Nuclear - metabolism</subject><subject>Regional Blood Flow - drug effects</subject><subject>Signal Transduction - drug effects</subject><subject>Soluble Guanylyl Cyclase</subject><subject>Swine</subject><subject>Time Factors</subject><subject>Vasodilation - drug effects</subject><subject>Vasodilator Agents - pharmacology</subject><subject>Vertebrates: cardiovascular system</subject><subject>Wine</subject><subject>Young Adult</subject><issn>0895-7061</issn><issn>1879-1905</issn><issn>1941-7225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqF0M-L1TAQB_AgivtcvXmWgIgXuyZNmiZHeeuuCwuKP49lmk7ZPtK0mzRK_3vzfM9d8OJpCPNhMvMl5DlnZ5wJ_RZ2N2cly6-yrB-QDde1Kbhh1UOyYdpURc0UPyFPYtwxxqRS_DE5KTnTWtViQ_AcBrfSz9jRH4NHup18TOO8DJOnV-Mcpp8Y6XeINjkI9CJ5-6fVrhTol8ml1iG9TOBXtzq6Xa2DiMU5zug79Av9BMvNL1ifkkc9uIjPjvWUfLt4_3X7obj-eHm1fXddWCnFUgAXzLYWADT0TIrOKNMaK5TqaqE7IQF7aEF1FUfFesErZmQ-FU1veF9ZcUpeH-bmxW8TxqUZh2jROfA4pdhoqQzjysgsX_4jd1MKPi_XcFbKyjAl66zeHJQNU4wB-2YOwwhhzajZp9_k9Jt9-k1OP_MXx6GpHbG7w3_jzuDVEeREwfUBvB3ivROmqmot7u-Y0vy_L-lBelhSwDuc0d7syW_QzKQq</recordid><startdate>20110201</startdate><enddate>20110201</enddate><creator>Botden, Ilse P.G.</creator><creator>Langendonk, Janneke G.</creator><creator>Meima, Marcel E.</creator><creator>Boomsma, Frans</creator><creator>Seynhaeve, Ann L.B.</creator><creator>Hagen, Timo L.M. ten</creator><creator>Danser, A.H. Jan</creator><creator>Sijbrands, Eric J.G.</creator><general>Oxford University Press</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20110201</creationdate><title>Daily Red Wine Consumption Improves Vascular Function by a Soluble Guanylyl Cyclase-Dependent Pathway</title><author>Botden, Ilse P.G. ; Langendonk, Janneke G. ; Meima, Marcel E. ; Boomsma, Frans ; Seynhaeve, Ann L.B. ; Hagen, Timo L.M. ten ; Danser, A.H. Jan ; Sijbrands, Eric J.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-a130cbcaaa8af043d969b9c366d738d34aefaba6d51e60f315094905e9f91f5c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Alcohol Drinking</topic><topic>Animals</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Blood and lymphatic vessels</topic><topic>Blood vessels and receptors</topic><topic>Cardiology. Vascular system</topic><topic>Cells, Cultured</topic><topic>Coronary Vessels - drug effects</topic><topic>Coronary Vessels - enzymology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Endothelial Cells - drug effects</topic><topic>Endothelial Cells - enzymology</topic><topic>Endothelin-1 - blood</topic><topic>Female</topic><topic>Forearm - blood supply</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Guanylate Cyclase - metabolism</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Medical sciences</topic><topic>Muscle, Smooth, Vascular - drug effects</topic><topic>Muscle, Smooth, Vascular - enzymology</topic><topic>Nitric Oxide - metabolism</topic><topic>Perfusion</topic><topic>Plethysmography</topic><topic>Receptors, Cytoplasmic and Nuclear - metabolism</topic><topic>Regional Blood Flow - drug effects</topic><topic>Signal Transduction - drug effects</topic><topic>Soluble Guanylyl Cyclase</topic><topic>Swine</topic><topic>Time Factors</topic><topic>Vasodilation - drug effects</topic><topic>Vasodilator Agents - pharmacology</topic><topic>Vertebrates: cardiovascular system</topic><topic>Wine</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Botden, Ilse P.G.</creatorcontrib><creatorcontrib>Langendonk, Janneke G.</creatorcontrib><creatorcontrib>Meima, Marcel E.</creatorcontrib><creatorcontrib>Boomsma, Frans</creatorcontrib><creatorcontrib>Seynhaeve, Ann L.B.</creatorcontrib><creatorcontrib>Hagen, Timo L.M. ten</creatorcontrib><creatorcontrib>Danser, A.H. Jan</creatorcontrib><creatorcontrib>Sijbrands, Eric J.G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Botden, Ilse P.G.</au><au>Langendonk, Janneke G.</au><au>Meima, Marcel E.</au><au>Boomsma, Frans</au><au>Seynhaeve, Ann L.B.</au><au>Hagen, Timo L.M. ten</au><au>Danser, A.H. Jan</au><au>Sijbrands, Eric J.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Daily Red Wine Consumption Improves Vascular Function by a Soluble Guanylyl Cyclase-Dependent Pathway</atitle><jtitle>American journal of hypertension</jtitle><addtitle>Am J Hypertens</addtitle><date>2011-02-01</date><risdate>2011</risdate><volume>24</volume><issue>2</issue><spage>162</spage><epage>168</epage><pages>162-168</pages><issn>0895-7061</issn><eissn>1879-1905</eissn><eissn>1941-7225</eissn><coden>AJHYE6</coden><abstract>Background
Polyphenols in red wine are supposed to improve endothelial function. We investigated whether daily red wine consumption improves in-vivo vascular function by reducing endothelin-1 (ET-1). Additional pathways mediating this effect were studied using porcine coronary arteries (PCAs).
Methods
Eighteen young healthy women drank red wine daily for 3 weeks. Vascular function was evaluated by determining forearm blood flow (FBF) responses to endothelium-dependent (acetylcholine
(ACh)) and endothelium-independent (sodium nitroprusside (SNP)) vasodilators. PCAs were suspended in organ baths and exposed to the endothelium-dependent vasodilator bradykinin, the nitric oxide (NO) donor S-nitroso-N-acetyl-l,l-penicillamine (SNAP) and/or red wine extract (RWE).
Results
ACh-induced and SNP-induced FBF increases were equally enhanced after 3 weeks of red wine consumption, but an immediate enhancement (i.e., after drinking the first glass) was not observed. Vice versa, plasma ET-1 levels were not decreased after 3 weeks, but we observed an acute drop after drinking one glass of wine. RWE relaxed preconstricted PCAs in an endothelium-, NO-, and soluble guanylyl cyclase (sGC)/guanosine-3′,5′-cyclic monophosphate (cGMP)-dependent manner. Short RWE exposure reduced the response to bradykinin and SNAP by inactivating sGC. This effect disappeared upon prolonged RWE exposure.
Conclusions
The enhanced FBF response following 3 weeks of red wine consumption, but not after one glass, reflects a change in smooth muscle sensitivity. Alterations in sGC responsiveness/activity, rather than changes in ET-1, appear to underlie this phenomenon.
American Journal of Hypertension,advance online publication 18 November 2010; doi:10.1038/ajh.2010.227</abstract><cop>Basingstoke</cop><pub>Oxford University Press</pub><pmid>21088673</pmid><doi>10.1038/ajh.2010.227</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0895-7061 |
| ispartof | American journal of hypertension, 2011-02, Vol.24 (2), p.162-168 |
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| source | Oxford Journals Online |
| subjects | Adult Alcohol Drinking Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Biomarkers - blood Blood and lymphatic vessels Blood vessels and receptors Cardiology. Vascular system Cells, Cultured Coronary Vessels - drug effects Coronary Vessels - enzymology Dose-Response Relationship, Drug Endothelial Cells - drug effects Endothelial Cells - enzymology Endothelin-1 - blood Female Forearm - blood supply Fundamental and applied biological sciences. Psychology Guanylate Cyclase - metabolism Humans In Vitro Techniques Medical sciences Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - enzymology Nitric Oxide - metabolism Perfusion Plethysmography Receptors, Cytoplasmic and Nuclear - metabolism Regional Blood Flow - drug effects Signal Transduction - drug effects Soluble Guanylyl Cyclase Swine Time Factors Vasodilation - drug effects Vasodilator Agents - pharmacology Vertebrates: cardiovascular system Wine Young Adult |
| title | Daily Red Wine Consumption Improves Vascular Function by a Soluble Guanylyl Cyclase-Dependent Pathway |
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