Clinical Pharmacology for Development of Topical Dermatological Products: Present and Future Opportunities for Safety and Efficacy

The development of topical products for dermatological diseases represents an untapped opportunity for the clinical pharmacologist. Assessment of bioavailability of topical drugs and its utility in weighing benefit vs. risk has been unique and challenging, compared with assessments for conventional...

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Bibliographic Details
Published in:Clinical pharmacology and therapeutics 2011-02, Vol.89 (2), p.167-169
Main Authors: Cho, S, Bashaw, ED
Format: Article
Language:English
Subjects:
Administration, Topical
Dermatologic Agents - adverse effects
Dermatologic Agents - pharmacokinetics
Dermatologic Agents - pharmacology
Drug Discovery
Humans
Pharmacology, Clinical
Skin - metabolism
Skin Diseases - drug therapy
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Summary:The development of topical products for dermatological diseases represents an untapped opportunity for the clinical pharmacologist. Assessment of bioavailability of topical drugs and its utility in weighing benefit vs. risk has been unique and challenging, compared with assessments for conventional systemic drugs. However, with continued advances in analytical methods and growing interests in discovering biomarkers, the future opportunities for clinical pharmacology to advance topical drug development processes are enormous and will be limited only by our drive and determination to push science forward. Clinical Pharmacology & Therapeutics (2011) 89 2, 167–169. doi:10.1038/clpt.2010.283
ISSN:0009-9236
1532-6535
DOI:10.1038/clpt.2010.283