Avian erythroblastosis: plasma clearance studies

In the terminal stages of erythroblastosis the clearance is reduced of some substances in the plasma that are normally removed by the liver and spleen. The plasma volume is increased, possibly because of the accumulation of hemoglobin and other products of cell breakdown. The erythrocyte volume rema...

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Bibliographic Details
Published in:Avian diseases 1970-08, Vol.14 (3), p.521-531
Main Authors: Darcel, C. le Q, Bide, R.W
Format: Article
Language:English
Subjects:
animal science
Animals
Avian Leukosis - blood
Avian Leukosis - metabolism
Avian Leukosis Virus
Bilirubin - blood
Blood
Blood - metabolism
Blood Chemical Analysis
Blood plasma
Blood Volume Determination
Carbon
Carbon - blood
Carbon - metabolism
Chickens
Dosage
Erythrocyte Count
Haptoglobins - blood
Haptoglobins - metabolism
Hematocrit
Heme - blood
Heme - metabolism
Hemoglobinometry
Hemoglobins
Hemoglobins - metabolism
Inoculation
Iron Isotopes
Liver
Liver - metabolism
Plasma volume
Spleen - metabolism
Sulfobromophthalein - blood
Sulfobromophthalein - metabolism
Viruses
zoology
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Summary:In the terminal stages of erythroblastosis the clearance is reduced of some substances in the plasma that are normally removed by the liver and spleen. The plasma volume is increased, possibly because of the accumulation of hemoglobin and other products of cell breakdown. The erythrocyte volume remains unchanged. Reduced clearance of haptoglobin-bound hemoglobin must contribute to the hemoglobinemia present in birds with erythroblastosis.
ISSN:0005-2086
1938-4351
DOI:10.2307/1588613