GELDANAMYCIN, A NEW ANTIBIOTIC

A new crystalline antimicrobial compound, geldanamycin, has been discovered in the culture nitrates of Streptomyces hygroscopicus var. geldanus var. nova. Geldanamycin is moderately active in vitro against protozoa, bacteria and fungi. It is also active against L-1210 and KB cells growing in culture...

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Bibliographic Details
Published in:Journal of antibiotics 1970, Vol.23(9), pp.442-447
Main Authors: DEBOER, C., MEULMAN, P.A., WNUK, R.J., PETERSON, D.H.
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - analysis
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Bacteria - drug effects
Chemical Phenomena
Chemistry
Chromatography
Chromatography, Paper
Chromatography, Thin Layer
Eukaryota - drug effects
Fungi - drug effects
Infrared Rays
Magnetic Resonance Spectroscopy
Mice
Microbial Sensitivity Tests
Spectrophotometry
Spectrum Analysis
Streptomyces - analysis
Ultraviolet Rays
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Summary:A new crystalline antimicrobial compound, geldanamycin, has been discovered in the culture nitrates of Streptomyces hygroscopicus var. geldanus var. nova. Geldanamycin is moderately active in vitro against protozoa, bacteria and fungi. It is also active against L-1210 and KB cells growing in culture and against the parasite Syphacia ohlevata, in vivo. The fermentation, assay, chromatography and isolation as well as its biological and chemical properties were investigated. On the basis of its physical and chemical properties, geldanamycin is a complex molecule consisting of an unsaturated moiety attached to a quinone.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.23.442