Background of Increased Flow Resistance and Vascular Reactivity in Spontaneously Hypertensive Rats

The hindquarters of a spontaneously hypertensive rat (SHR) and a matched normotensive control rat (NCR) were perfused at a constant rate of flow with oxygenated plasma substitute in 15 paired experiments. As is the case in the entire systemic vascular bed (Folkow et al. 1969), flow resistance was ra...

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Bibliographic Details
Published in:Acta physiologica Scandinavica 1970-09, Vol.80 (1), p.93-106
Main Authors: Folkow, Björn, Hallbäck, Margareta, Lundgren, Yen, Weiss, Lilian
Format: Article
Language:English
Subjects:
Animals
Blood Pressure
Blood Vessels - drug effects
Blood Vessels - physiopathology
Dilatation
Hypertension - physiopathology
Norepinephrine - pharmacology
Perfusion
Rats
Vascular Resistance
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Summary:The hindquarters of a spontaneously hypertensive rat (SHR) and a matched normotensive control rat (NCR) were perfused at a constant rate of flow with oxygenated plasma substitute in 15 paired experiments. As is the case in the entire systemic vascular bed (Folkow et al. 1969), flow resistance was raised even during maximal dilatation in SHR (p
ISSN:0001-6772
1365-201X
DOI:10.1111/j.1748-1716.1970.tb04773.x