Utility of Comprehensive Assessment of Strain Dyssynchrony Index by Speckle Tracking Imaging for Predicting Response to Cardiac Resynchronization Therapy

The strain delay index is reportedly a marker of dyssynchrony and residual myocardial contractility. The aim of this study was to test the hypothesis that a relatively simple version of the strain dyssynchrony index (SDI) can predict response to cardiac resynchronization therapy (CRT) and that combi...

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Published in:The American journal of cardiology 2011-02, Vol.107 (3), p.439-446
Main Authors: Tatsumi, Kazuhiro, MD, Tanaka, Hidekazu, MD, PhD, Yamawaki, Kouhei, MD, Ryo, Keiko, MD, Omar, Alaa Mabrouk Salem, MD, Fukuda, Yuko, MD, Norisada, Kazuko, MD, PhD, Matsumoto, Kensuke, MD, Onishi, Tetsuari, MD, PhD, Gorcsan, John, MD, Yoshida, Akihiro, MD, PhD, Kawai, Hiroya, MD, PhD, Hirata, Ken-ichi, MD, PhD
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Cardiac Resynchronization Therapy
Cardiology
Cardiology. Vascular system
Cardiovascular
Correlation analysis
Diagnostic Imaging
Echocardiography, Doppler
Female
Heart attacks
Heart Failure - diagnostic imaging
Heart Failure - therapy
Humans
Male
Medical imaging
Medical sciences
Medical treatment
Predictive Value of Tests
Prognosis
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Sensitivity and Specificity
Studies
Treatment Outcome
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Summary:The strain delay index is reportedly a marker of dyssynchrony and residual myocardial contractility. The aim of this study was to test the hypothesis that a relatively simple version of the strain dyssynchrony index (SDI) can predict response to cardiac resynchronization therapy (CRT) and that combining assessment of radial, circumferential, and longitudinal SDI can further improve the prediction of responders. A total of 52 patients who underwent CRT were studied. The SDI was calculated as the average difference between peak and end-systolic strain from 6 segments for radial and circumferential SDI and 18 segments for longitudinal SDI. Conventional dyssynchrony measures were assessed by interventricular mechanical delay, the Yu index, and radial dyssynchrony by speckle tracking strain. Response was defined as a ≥15% decrease in end-systolic volume after 3 months. Of the individual parameters, radial SDI ≥6.5% was the best predictor of response to CRT, with sensitivity of 81%, specificity of 81%, and an area under the curve of 0.87 (p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2010.09.038