Excessive maternal transmission of diabetes in Japanese families with young-onset type 2 diabetes and insulin secretion defect according to clinical features

The aim of the study is to identify the clinical characteristics of Japanese patients with young-onset type 2 diabetes (YT2D). Family history of diabetes and clinical data were collected for 30 unrelated males (from 11 to 20 years old at age of onset) and 20 females (from 10 to 20 years old at age o...

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Bibliographic Details
Published in:Acta diabetologica 2010-12, Vol.47 (Suppl 1), p.133-138
Main Authors: Otabe, Shuichi, Nakayama, Hitomi, Fukutani, Tomoka, Yuan, Xiaohong, Wada, Nobuhiko, Hashinaga, Toshihiko, Mitsui, Akiko, Kato, Tomoko, Inada, Chizuko, Tajiri, Yuji, Yamada, Kentaro
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age of Onset
Aged
Aged, 80 and over
C-Peptide - blood
Child
Children & youth
Diabetes
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - metabolism
Disease transmission
Female
Humans
Insulin - metabolism
Insulin Secretion
Internal Medicine
Japan - epidemiology
Male
Maternal-Fetal Exchange
Medicine
Medicine & Public Health
Metabolic Diseases
Middle Aged
Mothers
Original Article
Parents & parenting
Peptides
Pregnancy
Sex Factors
Young Adult
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Summary:The aim of the study is to identify the clinical characteristics of Japanese patients with young-onset type 2 diabetes (YT2D). Family history of diabetes and clinical data were collected for 30 unrelated males (from 11 to 20 years old at age of onset) and 20 females (from 10 to 20 years old at age of onset) with YT2D diagnosed at ≤20 years of age. Fasting C-peptide levels were measured in all, and glucagon stimulation tests were performed twice in six of them over several years. Moreover, 858 people with type 2 diabetes (T2D) diagnosed at >20 years of age were randomly recruited in order to compare the transmission pattern of them. Among the study subjects, 68% reported at least one parent with diabetes. Diabetes was more frequent among mothers than fathers of probands ( P  = 0.020), although this tendency was not observed in T2D diagnosed at >20 years of age. Fasting C-peptide levels of patients with diabetes duration of ≥10 years were significantly lower than for patients with diabetes duration of
ISSN:0940-5429
1432-5233
DOI:10.1007/s00592-009-0152-1