Lipoproteins of Bacterial Pathogens

Bacterial lipoproteins are a set of membrane proteins with many different functions. Due to this broad-ranging functionality, these proteins have a considerable significance in many phenomena, from cellular physiology through cell division and virulence. Here we give a general overview of lipoprotei...

Full description

Saved in:
Bibliographic Details
Published in:Infection and Immunity 2011-02, Vol.79 (2), p.548-561
Main Authors: Kovacs-Simon, A, Titball, R.W, Michell, S.L
Format: Article
Language:English
Subjects:
Bacteria - metabolism
Bacteria - pathogenicity
Bacteriology
Biological and medical sciences
Cell Membrane
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Bacterial - physiology
Lipoproteins - genetics
Lipoproteins - physiology
Microbiology
Minireviews
Miscellaneous
Virulence
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Bacterial lipoproteins are a set of membrane proteins with many different functions. Due to this broad-ranging functionality, these proteins have a considerable significance in many phenomena, from cellular physiology through cell division and virulence. Here we give a general overview of lipoprotein biogenesis and highlight examples of the roles of lipoproteins in bacterial disease caused by a selection of medically relevant Gram-negative and Gram-positive pathogens: Mycobacterium tuberculosis, Streptococcus pneumoniae, Borrelia burgdorferi, and Neisseria meningitidis. Lipoproteins have been shown to play key roles in adhesion to host cells, modulation of inflammatory processes, and translocation of virulence factors into host cells. As such, a number of lipoproteins have been shown to be potential vaccines. This review provides a summary of some of the reported roles of lipoproteins and of how this knowledge has been exploited in some cases for the generation of novel countermeasures to bacterial diseases.
ISSN:0019-9567
1098-5522
DOI:10.1128/iai.00682-10