Neural correlates of impulsivity factors in psychiatric patients and healthy volunteers: a voxel-based morphometry study

According to bottom-up/top-down models, impulsivity facets are represented across the cerebral cortex and subcortex. Hypothesized gray matter correlates of motor, attentional and non-planning impulsivity were examined in groups of 35 psychiatric patients characterized by self-control problems and 18...

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Bibliographic Details
Published in:Brain imaging and behavior 2011-03, Vol.5 (1), p.52-64
Main Authors: Lee, Athene K. W, Jerram, Matthew, Fulwiler, Carl, Gansler, David A
Format: Article
Language:English
Subjects:
Adult
Attention
Attention deficit hyperactivity disorder
Biomedical and Life Sciences
Biomedicine
Bipolar disorder
Brain - pathology
cerebellum
Cerebellum - pathology
Cerebral Cortex - pathology
Data Interpretation, Statistical
Female
Frontopolar cortex
Functional Laterality - physiology
Healthy controls
Humans
Image Processing, Computer-Assisted
Impulsive Behavior - pathology
Impulsive Behavior - psychology
Impulsivity
Magnetic Resonance Imaging
Male
Medical imaging
Neuroimaging
Neuropsychology
Neuroradiology
Neurosciences
Orbitofrontal cortex
Original Research
Prefrontal Cortex - pathology
Psychiatric patients
Psychiatry
Structural MRI
VBM
Voxel-based morphometry
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Summary:According to bottom-up/top-down models, impulsivity facets are represented across the cerebral cortex and subcortex. Hypothesized gray matter correlates of motor, attentional and non-planning impulsivity were examined in groups of 35 psychiatric patients characterized by self-control problems and 18 healthy volunteers. Among patients, a positive correlation was found between motor impulsivity and the right cerebellum, and a negative correlation emerged between attentional impulsivity and the left lateral orbitofrontal cortex (OFC). Among controls, attentional and motor impulsivity correlated negatively with the left superior temporal gyrus, while non-planning impulsivity correlated positively with the left OFC and lateral frontopolar cortex. Follow-up analyses revealed convergence in correlation patterns from patients to controls, but not vice versa. That pattern suggested broader neural representation of the trait in the healthy controls, who were less impulsive than the psychiatric patients.
ISSN:1931-7557
1931-7565
DOI:10.1007/s11682-010-9112-1