Indocyanine green fluorescence imaging system for sentinel lymph node biopsies in early breast cancer patients

Purpose This study presents a new method that enables the detection of sentinel lymph nodes (SLN) with high sensitivity using indocyanine green (ICG) fluorescence imaging. Methods This study enrolled 128 patients with clinically node-negative breast cancer. Fluorescence imaging was obtained after IC...

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Bibliographic Details
Published in:Surgery today (Tokyo, Japan) Japan), 2011-02, Vol.41 (2), p.197-202
Main Authors: Abe, Hajime, Mori, Tsuyoshi, Umeda, Tomoko, Tanaka, Makiko, Kawai, Yuki, Shimizu, Tomoharu, Cho, Hirotomi, Kubota, Yoshihiro, Kurumi, Yoshimasa, Tani, Tohru
Format: Article
Language:English
Subjects:
Adult
Aged
Breast Neoplasms - pathology
Female
Fluorescence
Humans
Indocyanine Green
Medicine
Medicine & Public Health
Middle Aged
Original Article
Sensitivity and Specificity
Sentinel Lymph Node Biopsy - methods
Surgery
Surgical Oncology
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Summary:Purpose This study presents a new method that enables the detection of sentinel lymph nodes (SLN) with high sensitivity using indocyanine green (ICG) fluorescence imaging. Methods This study enrolled 128 patients with clinically node-negative breast cancer. Fluorescence imaging was obtained after ICG was injected into the areola. Subcutaneous lymphatic channels were immediately visible. Results Lymphatic channels and SLN were successfully visualized in all patients. One lymphatic channel was 60%, two channels were 24%, and three channels were 16%. The number of fluorescence SLN ranged from 1 to 6, and blue-dyed SLN ranged from 0 to 3. In the latter, SLN were not identified in 44 patients. Nineteen patients had pathologically identified lymph node metastases. All of them were recognized by fluorescence imaging, but 8 patients had lymph nodes with metastases were not identified by dye method. Conclusion This ICG fluorescence imaging technique is feasible and safe for detecting SLN in a less invasive manner than conventional mapping, with real-time observations.
ISSN:0941-1291
1436-2813
DOI:10.1007/s00595-009-4254-8