Flow cytometry and its use in the diagnosis and management of mature lymphoid malignancies

de Tute R M
(2011) Histopathology 58, 90–105
Flow cytometry and its use in the diagnosis and management of mature lymphoid malignancies The last decade has seen major advances in flow cytometric immunophenotyping and this has expanded the utility of flow cytometry to investigate the antigens present...

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Bibliographic Details
Published in:Histopathology 2011-01, Vol.58 (1), p.90-105
Main Author: de Tute, Ruth M
Format: Article
Language:English
Subjects:
Animals
diagnosis
flow cytometry
Flow Cytometry - methods
Hematologic Neoplasms - diagnosis
Humans
Immunophenotyping
Leukemia - diagnosis
Leukemia - pathology
lymphoid neoplasm
lymphoma
Lymphoma - diagnosis
Lymphoma, B-Cell - diagnosis
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Summary:de Tute R M
(2011) Histopathology 58, 90–105
Flow cytometry and its use in the diagnosis and management of mature lymphoid malignancies The last decade has seen major advances in flow cytometric immunophenotyping and this has expanded the utility of flow cytometry to investigate the antigens present on normal and neoplastic haematopoietic cells. This review summarizes how flow cytometry is used currently in the diagnosis and management of mature lymphoid malignancies. The establishment of disease‐specific phenotypes allows the creation of assays which can detect neoplastic cells with high specificity and sensitivity. Certain lymphoid neoplasms are well defined immunophenotypically, while others are more heterogeneous. The availability of more sophisticated cytometers and a wider selection of antibodies in routine diagnostic laboratories will lead to the resolution of these more complex disease entities.
ISSN:0309-0167
1365-2559
DOI:10.1111/j.1365-2559.2010.03703.x