KSHV DNA viremia correlates with low CD4+ cell count in Italian Males at the time of diagnosis of HIV infection

To evaluate the relevance and the virological and immunological markers of Kaposi sarcoma herpesvirus 8 (KSHV) viremia in Italian male patients at the time of diagnosis of infection with HIV-1, 481 men infected with HIV were recruited consecutively. The presence of KSHV DNA was evaluated in peripher...

Full description

Saved in:
Bibliographic Details
Published in:Journal of medical virology 2011-03, Vol.83 (3), p.384-390
Main Authors: Parisi, Saverio G, Boldrin, Caterina, Andreis, Samantha, Ferretto, Roberto, Fuser, Rodolfo, Malena, Marina, Manfrin, Vinicio, Panese, Sandro, Scaggiante, Renzo, Dori, Luca, Sarmati, Loredana, Biasolo, Maria A, Nicastri, Emanuele, Andreoni, Massimo, Cruciani, Mario, Palù, Giorgio
Format: Article
Language:English
Subjects:
AIDS-Related Opportunistic Infections - immunology
Biological and medical sciences
CD4 Lymphocyte Count
DNA, Viral - analysis
Fundamental and applied biological sciences. Psychology
Herpesviridae Infections - complications
Herpesviridae Infections - immunology
Herpesvirus
Herpesvirus 8, Human
HIV
HIV Infections - complications
HIV Infections - immunology
HIV-1 - immunology
homosexual relationship
Human immunodeficiency virus 1
Human viral diseases
Humans
immunodeficiency
Infectious diseases
Italy
Kaposi's sarcoma-associated herpesvirus
KSHV DNA
Male
Medical sciences
Microbiology
Miscellaneous
Viral diseases
Viral Load
Viremia - complications
Viremia - immunology
Virology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To evaluate the relevance and the virological and immunological markers of Kaposi sarcoma herpesvirus 8 (KSHV) viremia in Italian male patients at the time of diagnosis of infection with HIV-1, 481 men infected with HIV were recruited consecutively. The presence of KSHV DNA was evaluated in peripheral blood mononuclear cells (PBMCs) and in plasma and correlated with demographic and viro-immunological parameters. Seventy-four patients had KSHV DNA detected in PBMCs. By univariate analysis, the presence of KSHV DNA was associated significantly with unprotected homosexual relationships (P = 0.003) and it was significantly higher in patients with CD4+ cell
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.21987