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Absorption, Distribution, and Excretion of Penicillin and Dihydrostreptomycin in Dairy Cows Following Intramammary Infusion
Six dairy cows were given intramammary infusions of penicillin and dihydrostreptomycin in a 3 replicate experiment with 3 treatments in 1, 2 and 4 quarters. Blood, milk and urine were collected after each test and muscle, fat, liver and kidney were assayed from each treatment after the third test. B...
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| Published in: | Journal of dairy science 1970-10, Vol.53 (10), p.1407-1414 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c4226-d930e1a7aacfe0b19be96a207b9b50129ed49d949ec17217583dc42bf1a3a6a93 |
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| cites | cdi_FETCH-LOGICAL-c4226-d930e1a7aacfe0b19be96a207b9b50129ed49d949ec17217583dc42bf1a3a6a93 |
| container_end_page | 1414 |
| container_issue | 10 |
| container_start_page | 1407 |
| container_title | Journal of dairy science |
| container_volume | 53 |
| creator | Rollins, L.D. Mercer, H.D. Carter, G.G. Kramer, J. |
| description | Six dairy cows were given intramammary infusions of penicillin and dihydrostreptomycin in a 3 replicate experiment with 3 treatments in 1, 2 and 4 quarters. Blood, milk and urine were collected after each test and muscle, fat, liver and kidney were assayed from each treatment after the third test.
Both antibiotics were detected in the milk beyond the recommended withdrawal time and also in the milk from untreated quarters. Peaks in sera were reached within 2 to 4 hours post-treatment and were directly related to the number of quarters treated. Some penicillin persisted in urine for 14 days and some dihydrostreptomycin persisted for 15 days. Both antibiotics were detected in the liver and kidney. There was more penicillin in the kidney medulla and more dihydrostreptomycin in the kidney cortex. |
| doi_str_mv | 10.3168/jds.S0022-0302(70)86408-6 |
| format | article |
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Both antibiotics were detected in the milk beyond the recommended withdrawal time and also in the milk from untreated quarters. Peaks in sera were reached within 2 to 4 hours post-treatment and were directly related to the number of quarters treated. Some penicillin persisted in urine for 14 days and some dihydrostreptomycin persisted for 15 days. Both antibiotics were detected in the liver and kidney. There was more penicillin in the kidney medulla and more dihydrostreptomycin in the kidney cortex.</description><identifier>ISSN: 0022-0302</identifier><identifier>EISSN: 1525-3198</identifier><identifier>DOI: 10.3168/jds.S0022-0302(70)86408-6</identifier><identifier>PMID: 4097376</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adipose Tissue - analysis ; animal science ; Animals ; Cattle ; Dihydrostreptomycin Sulfate - administration & dosage ; Dihydrostreptomycin Sulfate - analysis ; Dihydrostreptomycin Sulfate - blood ; Dihydrostreptomycin Sulfate - metabolism ; Dihydrostreptomycin Sulfate - urine ; Female ; Kidney - analysis ; Lactation ; Liver - analysis ; Mammary Glands, Animal - metabolism ; Milk - analysis ; Milk - metabolism ; Muscles - analysis ; Penicillins - administration & dosage ; Penicillins - analysis ; Penicillins - blood ; Penicillins - metabolism ; Penicillins - urine ; Pregnancy ; zoology</subject><ispartof>Journal of dairy science, 1970-10, Vol.53 (10), p.1407-1414</ispartof><rights>1970 American Dairy Science Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4226-d930e1a7aacfe0b19be96a207b9b50129ed49d949ec17217583dc42bf1a3a6a93</citedby><cites>FETCH-LOGICAL-c4226-d930e1a7aacfe0b19be96a207b9b50129ed49d949ec17217583dc42bf1a3a6a93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022030270864086$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3549,27924,27925,45780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4097376$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rollins, L.D.</creatorcontrib><creatorcontrib>Mercer, H.D.</creatorcontrib><creatorcontrib>Carter, G.G.</creatorcontrib><creatorcontrib>Kramer, J.</creatorcontrib><title>Absorption, Distribution, and Excretion of Penicillin and Dihydrostreptomycin in Dairy Cows Following Intramammary Infusion</title><title>Journal of dairy science</title><addtitle>J Dairy Sci</addtitle><description>Six dairy cows were given intramammary infusions of penicillin and dihydrostreptomycin in a 3 replicate experiment with 3 treatments in 1, 2 and 4 quarters. Blood, milk and urine were collected after each test and muscle, fat, liver and kidney were assayed from each treatment after the third test.
Both antibiotics were detected in the milk beyond the recommended withdrawal time and also in the milk from untreated quarters. Peaks in sera were reached within 2 to 4 hours post-treatment and were directly related to the number of quarters treated. Some penicillin persisted in urine for 14 days and some dihydrostreptomycin persisted for 15 days. Both antibiotics were detected in the liver and kidney. 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Blood, milk and urine were collected after each test and muscle, fat, liver and kidney were assayed from each treatment after the third test.
Both antibiotics were detected in the milk beyond the recommended withdrawal time and also in the milk from untreated quarters. Peaks in sera were reached within 2 to 4 hours post-treatment and were directly related to the number of quarters treated. Some penicillin persisted in urine for 14 days and some dihydrostreptomycin persisted for 15 days. Both antibiotics were detected in the liver and kidney. There was more penicillin in the kidney medulla and more dihydrostreptomycin in the kidney cortex.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>4097376</pmid><doi>10.3168/jds.S0022-0302(70)86408-6</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of dairy science, 1970-10, Vol.53 (10), p.1407-1414 |
| issn | 0022-0302 1525-3198 |
| language | eng |
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| source | ScienceDirect; EZB Electronic Journals Library |
| subjects | Adipose Tissue - analysis animal science Animals Cattle Dihydrostreptomycin Sulfate - administration & dosage Dihydrostreptomycin Sulfate - analysis Dihydrostreptomycin Sulfate - blood Dihydrostreptomycin Sulfate - metabolism Dihydrostreptomycin Sulfate - urine Female Kidney - analysis Lactation Liver - analysis Mammary Glands, Animal - metabolism Milk - analysis Milk - metabolism Muscles - analysis Penicillins - administration & dosage Penicillins - analysis Penicillins - blood Penicillins - metabolism Penicillins - urine Pregnancy zoology |
| title | Absorption, Distribution, and Excretion of Penicillin and Dihydrostreptomycin in Dairy Cows Following Intramammary Infusion |
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