Incidence of thyroid carcinoma in Graves' disease

In a consecutive series of 172 patients with Graves' disease treated by total thyroidectomy, 15 patients (9%) had an associated unsuspected carcinoma. There were 20 patients who had received prior treatment with radioactive iodine; 3 (15%) had carcinoma. The high incidence of thyroid carcinoma...

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Bibliographic Details
Published in:Cancer 1970-12, Vol.26 (6), p.1261-1270
Main Authors: Shapiro, Stephen J., Friedman, Nathan B., Perzik, S. L., Catz, Boris
Format: Article
Language:English
Subjects:
Adenocarcinoma - complications
Adenocarcinoma - pathology
Adenocarcinoma, Papillary - complications
Adenocarcinoma, Papillary - pathology
Adolescent
Adult
Carcinoma - complications
Carcinoma - pathology
Child
Cystadenocarcinoma - complications
Cystadenocarcinoma - pathology
Female
Graves Disease - complications
Graves Disease - radiotherapy
Graves Disease - surgery
Humans
Iodine Isotopes - therapeutic use
Male
Middle Aged
Thyroid Neoplasms - complications
Thyroid Neoplasms - pathology
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Summary:In a consecutive series of 172 patients with Graves' disease treated by total thyroidectomy, 15 patients (9%) had an associated unsuspected carcinoma. There were 20 patients who had received prior treatment with radioactive iodine; 3 (15%) had carcinoma. The high incidence of thyroid carcinoma found in this series suggests that when surgery is elected as the treatment of choice in any given case of Graves' disease, nothing less than a total thyroidectomy should be performed. This high incidence would further indicate that surgery should be given even greater consideration in the selection of a modality for the management of any specific case of Graves' disease.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(197012)26:6<1261::AID-CNCR2820260613>3.0.CO;2-P