Leukemia Virus Suppression of Antibody-Forming Cells: Ultrastructure of Infected Spleens

Infection of adult BALB/c mice with Friend disease virus results in a leukemia-like disease characterized by erythropoietic changes and splenomegaly. A marked depression of formation of cellular and serum antibody occurs in infected animals. Electron-microscopic examination of the ultrastructure of...

Full description

Saved in:
Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1968-01, Vol.159 (3813), p.437-439
Main Authors: Chan, Gloria, Rancourt, Martha W., Ceglowski, Walter S., Friedman, Herman
Format: Article
Language:English
Subjects:
Animals
Antibodies
Antibody Formation
Cellular immunity
Erythrocytes
Friend murine leukemia virus - pathogenicity
Hemolysin Proteins - biosynthesis
Immunization
Inclusion Bodies, Viral
Infections
Leukemia, Experimental - immunology
Leukemia, Experimental - pathology
Lymphocytes
Lymphocytes - microbiology
Mice
Microscopy, Electron
Plasma cells
Spleen
Spleen - immunology
Spleen - microbiology
Spleen - pathology
Spleen cells
Splenomegaly
Stem cells
Viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Infection of adult BALB/c mice with Friend disease virus results in a leukemia-like disease characterized by erythropoietic changes and splenomegaly. A marked depression of formation of cellular and serum antibody occurs in infected animals. Electron-microscopic examination of the ultrastructure of spleen sections from infected mice with depressed immunity revealed that virus particles can be detected only in immature blastlike lymphoid cells and not in plasmocytes characteristic of the immune response in spleens of noninfected mice immunized with sheep erythrocytes.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.159.3813.437