A case of splenic low-grade mucinous cystadenocarcinoma resulting in pseudomyxoma peritonei

Primary splenic mucinous cystadenocarcinoma (MCCa) is extremely rare, and only six cases appear to have been reported previously. We present herein a case of primary splenic MCCa resulting in pseudomyxoma peritonei (PMP). A 66-year-old Japanese woman presented to a hospital with a chief complaint of...

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Bibliographic Details
Published in:Medical molecular morphology 2010-12, Vol.43 (4), p.235-240
Main Authors: Ohe, Chisato, Sakaida, Noriko, Yanagimoto, Yasuaki, Toyokawa, Hideyoshi, Satoi, Sohei, Kwon, A. -Hon, Tadokoro, Chika, Takasu, Kosho, Uemura, Yoshiko
Format: Article
Language:English
Subjects:
Aged
Anatomy
Cancer
Cystadenocarcinoma, Mucinous - pathology
Cystadenocarcinoma, Mucinous - surgery
Female
Humans
Magnetic Resonance Imaging - methods
Medicine
Medicine & Public Health
Molecular Medicine
Mucous membrane
Original Paper
Pathology
Peritoneal Neoplasms - pathology
Peritoneal Neoplasms - surgery
Pseudomyxoma Peritonei - pathology
Pseudomyxoma Peritonei - surgery
Spleen
Splenectomy - methods
Splenic Neoplasms - pathology
Splenic Neoplasms - surgery
Tumors
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Summary:Primary splenic mucinous cystadenocarcinoma (MCCa) is extremely rare, and only six cases appear to have been reported previously. We present herein a case of primary splenic MCCa resulting in pseudomyxoma peritonei (PMP). A 66-year-old Japanese woman presented to a hospital with a chief complaint of upper abdominal pain and a 7-year history of splenic cyst. Cyst rupture was noted on computed tomography, and splenectomy was performed. The abdominal cavity was filled with a large amount of gelatinous ascites, with the appearance of PMP. On the cut surface, multiple cysts containing mucinous material were found within and outside the spleen. Microscopically, splenic parenchyma was occupied by large mucinous pools focally lined with mucinous epithelial cells and mesothelial cell-like cells, which were considered benign. Outside the spleen, a low-grade MCCa component was found. No ectopic pancreatic or intestinal tissue was identified. Although most PMP cases are known to be caused by low-grade mucinous appendiceal tumor, the present case represents the first report of a splenic MCCa resulting in PMP.
ISSN:1860-1480
1860-1499
DOI:10.1007/s00795-010-0507-2