Intratympanic injection with dexamethasone for sudden sensorineural hearing loss

To investigate the efficacy of intratympanic steroid therapy in adults with sudden sensorineural hearing loss, and to analyse the factors associated with treatment outcome. Retrospective study of patients undergoing intratympanic steroid injection for sudden sensorineural hearing loss between 1 Janu...

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Bibliographic Details
Published in:Journal of laryngology and otology 2011-02, Vol.125 (2), p.133-137
Main Authors: Tsai, Y-J, Liang, J-G, Wu, W-B, Ding, Y-F, Chiang, R P-Y, Wu, S-M
Format: Article
Language:English
Subjects:
Adult
Aged
Anti-Inflammatory Agents - administration & dosage
Anti-Inflammatory Agents - therapeutic use
Audiometry
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Dexamethasone - administration & dosage
Dexamethasone - therapeutic use
Diabetes
Dose-Response Relationship, Drug
Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology
Ears & hearing
Female
Hearing loss
Hearing Loss, Sensorineural - drug therapy
Hearing Loss, Sudden - drug therapy
Hearing protection
Hospitals, Teaching
Humans
Hypertension
Male
Medical sciences
Middle Aged
Non tumoral diseases
Otorhinolaryngology. Stomatology
Patients
Pharmacology. Drug treatments
Recovery of Function
Response rates
Retrospective Studies
Steroids
Taiwan
Time Factors
Treatment Outcome
Tympanic Membrane
Vertigo
Vertigo - complications
Viral infections
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Summary:To investigate the efficacy of intratympanic steroid therapy in adults with sudden sensorineural hearing loss, and to analyse the factors associated with treatment outcome. Retrospective study of patients undergoing intratympanic steroid injection for sudden sensorineural hearing loss between 1 January 2006 and 30 June 2007 at a teaching hospital in Taipei, Taiwan. Patients who received intratympanic steroid therapy within seven days of disease onset achieved a significantly better response rate (76.1 per cent), compared with the delayed treatment group (50 per cent). The total response rate, after four steroid injections, was 68.9 per cent. Patients with low and mid-frequency hearing loss were more responsive to steroid treatment. Vertigo was a negative prognostic factor for recovery. There were no long-term sequelae of intratympanic steroid treatment. Intratympanic steroid injection may be a simple and effective treatment for patients with sudden sensorineural hearing loss.
ISSN:0022-2151
1748-5460
DOI:10.1017/S0022215110002124