Prediction of Clinical Course of Glioblastomas by MRI during Radiotherapy

Purpose: Determine the value of MR studies in patients undergoing radiotherapy for glioblastomas pre and during radiotherapy to predict the clinical course. Patients and Methods: MR follow-up studies were performed in 33 patients with glioblastomas before radiotherapy, after 30 Gy, after 60 Gy, and...

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Bibliographic Details
Published in:Strahlentherapie und Onkologie 2010-12, Vol.186 (12), p.681-686
Main Authors: Leitzen, Christina, Schild, Hans H., Bungart, Birgitta, Herrlinger, Ulrich, Lütter, Christiana, Müdder, Thomas, Wilhelm-Buchstab, Timo, Schüller, Heinrich
Format: Article
Language:ger
Subjects:
Adult
Aged
Brain Neoplasms - drug therapy
Brain Neoplasms - mortality
Brain Neoplasms - pathology
Brain Neoplasms - radiotherapy
Brain Neoplasms - surgery
Chemotherapy, Adjuvant
Combined Modality Therapy
Cranial Irradiation
Diffusion Magnetic Resonance Imaging
Disease Progression
Female
Follow-Up Studies
Glioblastoma - drug therapy
Glioblastoma - mortality
Glioblastoma - pathology
Glioblastoma - radiotherapy
Glioblastoma - surgery
Humans
Image Enhancement
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Recurrence, Local - mortality
Oncology
Originalarbeit
Prognosis
Radiotherapy
Radiotherapy Dosage
Survival Rate
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Summary:Purpose: Determine the value of MR studies in patients undergoing radiotherapy for glioblastomas pre and during radiotherapy to predict the clinical course. Patients and Methods: MR follow-up studies were performed in 33 patients with glioblastomas before radiotherapy, after 30 Gy, after 60 Gy, and in the treatment follow-up. Findings on MR were categorized into: definite progress, questionable progress, status idem. Patients were followed clinically (median for 11 months). Results: After 30 Gy 23/33 (70%) of the MR examination showed status idem. 10/33 (30%) demonstrated definite (n = 6) or questionable (n = 4) progress. Further tumor progress was faster in these patients and patients succumb to their disease earlier (9 vs. 22 months). The 60 Gy study showed definite (n = 8) and questionable (n = 6) progress in 14/33 (42%) cases. All these tumors were progressing faster and were associated with a comparatively reduced life expectancy. Conclusion: MR follow-up studies after 30 Gy in patients undergoing radiotherapy for glioblastomas allow for prognostic appraisal, and potentially early modification of treatment.
ISSN:0179-7158
1439-099X
DOI:10.1007/s00066-010-2156-8